ArticleAsian journal of neurosurgery2026
Neuropsychological Outcomes of Long-Term STN-DBS in Parkinson's Disease: A Multidomain Study in a Turkish Cohort.
Article in Asian journal of neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to evaluate the long-term neuropsychological outcomes and cognitive safety of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) compared with standard medical therapy (MED) in patients with Parkinson's disease (PD). Materials and Methods: This single-center, cross-sectional study included 56 patients with idiopathic PD (STN-DBS = 32; MED = 24), all evaluated in the on-medication state under stable treatment conditions. A concise multidomain neuropsychological battery was administered, including phonemic and semantic verbal fluency, Stroop test (time, errors, corrections), forward and backward digit span, judgment of line orientation, clock drawing, and Mini-Mental State Examination. Clinical assessments comprised Unified PD Rating Scale part III, Hoehn-Yahr stage, PD Questionnaire-39, and Hamilton Anxiety and Depression scales. The two groups were matched for age, sex, education level, motor phenotype, and on-state motor severity, while disease duration was considered in comparative analyses. Results: Compared with the MED group, patients with STN-DBS demonstrated lower phonemic verbal fluency, shorter forward digit span, and higher Stroop error counts. Differences in forward digit span and Stroop performance persisted after considering disease duration, whereas the phonemic fluency difference was attenuated. Semantic fluency, visuospatial abilities, and global cognitive performance did not differ between groups. Within the STN-DBS cohort, higher motor severity was associated with poorer semantic fluency and clock drawing performance, while no associations were observed between DBS duration and neuropsychological outcomes. Conclusion: Long-term STN-DBS is associated with selective modulation of attention and executive control functions, while global cognition, semantic fluency, and visuospatial abilities remain largely preserved. These findings support the relative cognitive safety of chronic STN-DBS and underscore the importance of routine executive function monitoring during long-term follow-up.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.