Evidence map›Paper›PMID 42535262›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.

James D LeFevre, Yukti Vyas, Aditi Sathe, Niranjana Shashikumar, Kimberly R Pechman, Yisu Yang, Alaina Durant, Praitayini Kanakaraj, Michael E Kim, Chenyu Gao and 27 more

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

James D LeFevreVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Yukti VyasVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Aditi SatheVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Niranjana ShashikumarVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Kimberly R PechmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Yisu YangVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Alaina DurantVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Praitayini KanakarajDepartment of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Michael E KimDepartment of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Chenyu GaoDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Nancy R NewlinDigital Informatics & Technology Solutions, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Karthik RamadassDepartment of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Nazirah Mohd KhairiDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Zhiyuan LiDepartment of Computer Science, Park University, Parkville, Missouri, USA.
Tianyuan YaoDepartment of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Shannon L RisacherDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Panpan ZhangVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Kurt G SchillingDepartment of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Annie J LeeDepartment of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
Adam M BrickmanDepartment of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
Richard MayeuxDepartment of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
Jesse MezDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Alzheimer's Disease Neuroimaging Initiative (ADNI)
Alzheimer's Disease Sequencing Project (ADSP)The ADSP Phenotype Harmonization Consortium (ADSP‐PHC)
Walter KukullDepartment of Neurology, Washington University at St. Louis, St. Louis, Missouri, USA.
Sarah A BiberDepartment of Neurology, Washington University at St. Louis, St. Louis, Missouri, USA.
Bennett A LandmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Barbara B BendlinWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Sterling C JohnsonWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Julie SchneiderVanderbilt Alzheimer's Disease Research Center, Vanderbilt University, Nashville, Tennessee, USA.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
David A BennettVanderbilt Alzheimer's Disease Research Center, Vanderbilt University, Nashville, Tennessee, USA.
Andrew J SaykinDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Michael L CuccaroThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Timothy J HohmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Angela L JeffersonVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Derek B ArcherVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MONICA G. RIVERA-MINDT · 2016 to 2026
$226.7M
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 1991 to 2020
$49.1M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
MVP Data Integration into the ADSP Phenotype Harmonization ConsortiumU24AG074855 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUCCARO, MICHAEL L, HOHMAN, TIMOTHY J · 2021 to 2025
$37.5M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Sudeshna Das · 2019 to 2026
$36.5M
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5M
DOD ADNIIllinois Department of Public Health (Alzheimer's Disease Research Fund)NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NIA NIH HHS AG-021155NIA NIH HHS AG-0271761NIA NIH HHS AG-037639NIA NIH HHS AG-054047NIA NIH HHS K01 AG073584NIA NIH HHS K01 AG084849NIA NIH HHS K24 AG046373NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072931NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072973NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072978NIA NIH HHS P30 AG072979NIA NIH HHS P30 AG086401NIA NIH HHS P30 AG086404NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG034962NIA NIH HHS R01 AG056405NIA NIH HHS R01 AG056534NIA NIH HHS R01 AG059716NIA NIH HHS R01 AG064233NIA NIH HHS R01 AG067482NIA NIH HHS R01 AG079280NIA NIH HHS RF1 AG015819NIA NIH HHS RF1 AG022018NIA NIH HHS T32 AG058524NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG068057NIA NIH HHS U19 AG024904NIA NIH HHS U24 AG072122NIA NIH HHS U24 AG074855NIBIB NIH HHS K01 EB032898NIBIB NIH HHS R01 EB017230NIH HHS S10 OD021771NIH HHS S10 OD023680NINDS NIH HHS R01 NS100980NINDS NIH HHS U01 NS100599NINDS NIH HHS UF1 NS100599NINDS NIH HHS UH2 NS100599NINDS NIH HHS UH3 NS100599the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health U19-AG024904
6 · The paper itself

Abstract

introductionVascular risk factors (VRFs) contribute to white matter microstructural degeneration, but their tract-specific contributions are unclear. We assessed the independent associations of four major VRFs with white matter microstructure in a large, multi-cohort study.

methodsDiffusion magnetic resonance imaging data from five harmonized cohorts were free water (FW) corrected (n = 2961, 73.00 ± 9.27 years, 59.34% female). We associated body mass index (BMI) and presence of hypertension, diabetes, and heart disease with FW and FW-corrected diffusion metrics (fractional anisotropy, mean diffusivity, axial diffusivity, radial diffusivity) in 48 tracts.

resultsHypertension and heart disease showed the most robust and widespread independent associations with white matter microstructure. In contrast, diabetes associations were attenuated in sensitivity analyses, while BMI associations were inconsistent across metrics. DISCUSSION: Hypertension and heart disease are associated most strongly with white matter microstructure, suggesting that tighter management of these conditions may more reliably yield benefits in preserving white matter health.

Indexed as

BrainWhite MatterAgedAged, 80 and overBody Mass IndexCohort StudiesDiabetes MellitusDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFemaleHeart Disease Risk FactorsHeart DiseasesHumansHypertensionMaleRisk Factorsagingdiffusion tensor imagingtractographyvascular risk factorswhite matter microstructure

Identifiers

PMID42535262
PMCPMC13425621

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.