ArticleInternational journal of molecular medicine2026
Energy stress activates AMPK to suppress ferroptosis in neurodegenerative proteinopathies.
Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ferroptosis, an iron‑dependent and lipid peroxidation‑driven form of regulated cell death, has emerged as a key contributor to neuronal degeneration in protein misfolding disorders. However, how cellular energy metabolism modulates ferroptotic susceptibility in neurodegenerative proteinopathies remains incompletely defined. The present study investigated whether the previously described energy stress‑AMP-activated protein kinase (AMPK)‑acetyl‑CoA carboxylase (ACC) ferroptosis checkpoint operates in disease‑relevant neuronal proteinopathy models. Pharmacological and genetic interventions, cell viability assays, lipid peroxidation measurements, western blotting, RNA interference, and behavioral analyses were performed in SH‑SY5Y cells, transgenic
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