ArticleSmall (Weinheim an der Bergstrasse, Germany)2026
Remote-Controlled Release of Nitric Oxide by Plasmonic Waveguide Coated With Metal-Organic Frameworks.
Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
10 authors.
Funding
Abstract
Spatiotemporal control of photochemical reactions in living cells is a powerful approach for the precise manipulation of cellular functions and the interrogation of biological systems. However, conventional methods requiring direct light exposure often induce cellular damage due to the generation of reactive oxygen species and/or photothermal effects. Here, we present a novel intracellular delivery method using the plasmonic waveguiding effect, which enables the release of bioactive molecules within a single live cell without subjecting the target cells to direct light exposure. This is achieved by remotely inducing photo-cleavage reactions via the propagation of surface plasmon polaritons (SPPs), which are generated by light irradiation at a spatially separated coupling point and guided to the target site. We demonstrate the efficacy of this platform by delivering nitric oxide (NO) gas into an individual single live cell, confirming its biological relevance by monitoring transient changes in intracellular calcium concentration. This novel platform provides a precise, time-controlled means of intracellular molecular delivery, offering a new frontier for minimizing invasive single-cell surgery and signaling studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.