Evidence map›Paper›PMID 42535427›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Shear-Responsive Red Blood Cell Carriers for Targeted Drug Delivery to Constricted Arteries.

Danielle Nemcovsky Amar, Rukiye Tuna, Tirosh Mekler, Merav Belenkovich, Dmitry Korneyev, Yevgeniy Kreinin, Anat Glozman, Josué Sznitman, Donald E Ingber, Zixiang Leonardo Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Danielle Nemcovsky AmarDepartment of Biomedical Engineering, Technion Israel Institute of Technology, Technion City, Haifa, Israel.ORCID https://orcid.org/0009-0008-7914-7932
Rukiye TunaDepartment of Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, Florida, USA.ORCID https://orcid.org/0009-0006-4912-8103
Tirosh MeklerDepartment of Biomedical Engineering, Technion Israel Institute of Technology, Technion City, Haifa, Israel.ORCID https://orcid.org/0009-0008-7921-7064
Merav BelenkovichDepartment of Biomedical Engineering, Technion Israel Institute of Technology, Technion City, Haifa, Israel.
Dmitry KorneyevDepartment of Biomedical Engineering, Technion Israel Institute of Technology, Technion City, Haifa, Israel.
Yevgeniy KreininDepartment of Biomedical Engineering, Technion Israel Institute of Technology, Technion City, Haifa, Israel.ORCID https://orcid.org/0009-0001-5713-9981
Anat GlozmanDepartment of Biomedical Engineering, Technion Israel Institute of Technology, Technion City, Haifa, Israel.
Josué SznitmanDepartment of Biomedical Engineering, Technion Israel Institute of Technology, Technion City, Haifa, Israel.ORCID https://orcid.org/0000-0001-8217-3842
Donald E IngberWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-4319-6520
Zixiang Leonardo LiuDepartment of Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, Florida, USA.ORCID https://orcid.org/0000-0001-7487-450X
Netanel KorinDepartment of Biomedical Engineering, Technion Israel Institute of Technology, Technion City, Haifa, Israel.ORCID https://orcid.org/0000-0001-7244-889X

Funding

European Research CouncilEuropean Union's Horizon 2020 research and innovation programme 101002057Wyss Institute for Biologically Inspired Engineering at Harvard University
6 · The paper itself

Abstract

Red blood cells (RBCs) are widely utilized as natural drug delivery systems due to their unique mechanical properties, which enable prolonged circulation and physiological function. This study examines a biophysical strategy that employs shear-responsive RBC (sr-RBC) carriers to mechanically release drugs at stenotic arteries. Intracellularly loaded sr-RBCs exhibited shear-dependent cargo release when perfused through stenotic arterial models, while no release was observed in unconstricted vessels. Notably, the sheared sr-RBCs retained their membrane integrity and CD47 expression while maintaining their ability to traverse microvascular networks without release when perfused through a microfluidic model simulating pulmonary capillaries. Multiscale modelling of RBC suspension fluid dynamics demonstrates a strong positive correlation between the sr-RBC drug release and the overall RBC membrane stretching induced by the high shear rates at various stenotic percentages. Sr-RBCs and mechanosensitive cell carriers may enable new avenues for treating life-threatening arterial constrictions and other vascular diseases.

Indexed as

ArteriesDrug CarriersDrug Delivery SystemsErythrocytesAnimalsHumansDrug Carrierscardiovascular diseasecell mechanicsdrug deliveryhemodynamicsmechano‐therapeuticsred blood cellsstenosis

Identifiers

PMID42535427
PMCPMC13580257

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.