ArticleClinical and translational science2026
Human Pharmacokinetic Prediction of Antibody-Drug Conjugates Using Human FcRn Transgenic Mice.
Article in Clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antibody-drug conjugates (ADCs) have progressed significantly in recent years, particularly in the oncology field. However, predicting human pharmacokinetics (PK) of ADCs in the early stages of drug development remains challenging. Human neonatal Fc receptor (FcRn) transgenic mice have been established as a reliable pre-clinical PK model for predicting human PK profiles of antibody-based therapeutics. In this study, we investigated the applicability of human FcRn transgenic mice for predicting the human PK of ADCs in a pre-clinical setting. Eight FDA-approved ADCs were administered to human FcRn transgenic mice, and PK parameters were calculated using two-compartment model analysis. The clearance (CL) values of total ADCs in human FcRn transgenic mice showed a strong correlation with human CL (R
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