Evidence map›Paper›PMID 42536239›Full record

ArticleAnnals of surgical oncology2026

Urine Cell-Free DNA in the Diagnosis of Intraductal Papillary Mucinous Neoplasms: A Prospective Observational Study.

Masatoshi Sato, Yuji Kitahata, Yuki Nakamura, Hideki Motobayashi, Norio Takemoto, Tomoki Nakai, Takahiko Hyo, Masaki Ueno, Shinya Hayami, Atsushi Miyamoto and 4 more

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Masatoshi SatoSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Yuji KitahataSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan. yu-kitahata@hyo-med.ac.jp.
Yuki NakamuraSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Hideki MotobayashiSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Norio TakemotoSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Tomoki NakaiSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Takahiko HyoSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Masaki UenoSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Shinya HayamiSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Atsushi MiyamotoSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Atsushi ShimizuSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Tomohiro YoshimuraSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Kyohei MatsumotoSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Manabu KawaiSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraductal papillary mucinous neoplasm (IPMN) is a typical precursor lesion of pancreatic cancer, but differential diagnosis and grading of IPMN is often difficult. Currently, grading of diagnosis is based mainly on imaging examinations, but these methods are invasive, and the accuracy is unsatisfactory. Therefore, the current study aimed to determine the usefulness of urine cell-free DNA (cfDNA) as a liquid biopsy, which the authors suggest has potential as a less invasive diagnostic tool for IPMN.

methodsPreoperative plasma and urine samples were collected from 33 patients with a preoperative diagnosis of IPMN. From their plasma and urine, cfDNA was extracted. Analysis of GNAS and KRAS mutations in the cfDNA was performed using droplet digital polymerase chain reaction.

resultsThe final diagnosis was IPMN in 31 of the 33 cases according to the resected specimens. The positivity rate of GNAS mutations in these 31 patients was 10 % (3/31) in plasma cfDNA, and 32 % (10/31) in urine cfDNA. The positivity rate of KRAS mutations was 19 % (6/31) in plasma cfDNA and 58 % (18/31) in urine cfDNA. In the multivariate analysis of the malignancy diagnosis, the main pancreatic duct diameter was ≥10 mm, and the positivity of both GNAS and KRAS mutations in urine cfDNA were significantly associated with IPMN malignancy (odds ratio [OR], 12.70; P = 0.0200; OR, 8.10; P = 0.0269).

conclusionsUrine cfDNA involves a less invasive liquid biopsy and seems to be useful in the diagnosis of IPMN.

Indexed as

Cell free DNADiagnostic biomarkerIntraductal mucinous neoplasmLiquid biopsyUrine

Identifiers

PMID42536239

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.