Evidence map›Paper›PMID 42536280›Full record

ReviewHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2026

Pathophysiology and Clinical Relevance of Microvascular Remodeling in Arterial Hypertension.

Matteo Lemoli, Claudia Agabiti Rosei, Giacomo Buso, Claudia Rossini, Luigi Mori, Damiano Rizzoni, Massimo Salvetti, Maria Lorenza Muiesan, Carolina De Ciuceis

Abstract readReview
PubMed Publisher
In one paragraph

Review in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matteo LemoliDivision of Internal Medicine, Department of Clinical and Experimental Sciences, ASST Spedali Civili Brescia, University of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy.
Claudia Agabiti RoseiDivision of Internal Medicine, Department of Clinical and Experimental Sciences, ASST Spedali Civili Brescia, University of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy.
Giacomo BusoDivision of Internal Medicine, Department of Clinical and Experimental Sciences, ASST Spedali Civili Brescia, University of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy.
Claudia RossiniDivision of Internal Medicine, Department of Clinical and Experimental Sciences, ASST Spedali Civili Brescia, University of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy.
Luigi MoriDivision of Internal Medicine, Department of Clinical and Experimental Sciences, ASST Spedali Civili Brescia, University of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy.
Damiano RizzoniDivision of Internal Medicine, Department of Clinical and Experimental Sciences, ASST Spedali Civili Brescia, University of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy.
Massimo SalvettiDivision of Internal Medicine, Department of Clinical and Experimental Sciences, ASST Spedali Civili Brescia, University of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy.
Maria Lorenza MuiesanDivision of Internal Medicine, Department of Clinical and Experimental Sciences, ASST Spedali Civili Brescia, University of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy.
Carolina De CiuceisDivision of Internal Medicine, Department of Clinical and Experimental Sciences, ASST Spedali Civili Brescia, University of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy. carolina.deciuceis@unibs.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term exposure to high blood pressure leads to systemic structural and functional changes of microcirculation, a condition named microvascular remodeling. Microvascular remodeling can be assessed in subcutaneous small resistance arteries or non-invasively at the retinal level using Scanning Laser Doppler Flowmetry and Adaptive Optics. Capillary rarefaction is also a marker of hypertensive vascular impairment resulting in a lack of nutrient and oxygen supply. In hypertension, microvascular remodeling and large artery damage are part of a vicious cycle that eventually leads to target organ damage and worsen cardio-renal-cerebrovascular outcomes. This review describes the inflammatory nature of microvascular remodeling and aims to unravel the association of microvascular remodeling with hypertension-mediated organ damage, also providing an overview on its clinical relevance.

Indexed as

CapillariesHypertensionMicrocirculationMicrovascular damageSmall resistance arteries

Identifiers

PMID42536280

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.