ArticlePLoS pathogens2026
Natural Killer Cell Granule Protein (NKG7) promotes the development of vaccine-induced anti-fungal Th1 cells.
Marcel Wüthrich, Cleison Ledesma Taira, Lucas Dos Santos Dias, Xin He, Sarah Lichtenberger, Bruce S Klein
Abstract read
In one paragraphArticle in PLoS pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors.
Marcel WüthrichDepartments of Pediatrics, University of Wisconsin, Madison, Wisconsin, United States of America.ORCID 0000-0002-2781-7876 Cleison Ledesma TairaDepartments of Pediatrics, University of Wisconsin, Madison, Wisconsin, United States of America.
Lucas Dos Santos DiasFungal Pathogenesis Section, Laboratory of Clinical Immunology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
Xin HeDepartments of Pediatrics, University of Wisconsin, Madison, Wisconsin, United States of America.
Sarah LichtenbergerDepartments of Pediatrics, University of Wisconsin, Madison, Wisconsin, United States of America.
Bruce S KleinDepartments of Pediatrics, University of Wisconsin, Madison, Wisconsin, United States of America.
Funding
PROTECTIVE IMMUNE RESPONSES TO BLASTOMYCES DERMATITIDISR01AI040996 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, WUETHRICH, MARCEL · 1997 to 2023
$10.4MMolecular Pathogenesis of BlastomycosisR37AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRUCE Steven KLEIN · 2004 to 2026
$6.9MNovel Combination Adjuvant for Eliciting Systemic and Mucosal CD8 T Cell MemoryU01AI124299 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, SURESH, MARULASIDDAPPA · 2016 to 2025
$6.2MRegulation of vaccine-induced anti-fungal Th17 cellsR01AI093553 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI WUETHRICH, MARCEL · 2011 to 2020
$4.5MMOLECULAR PATHOGENESIS OF BLASTOMYCOSISR01AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 1995 to 2019
$3.9MFungal Antigen Resources for Development of Vaccines and DiagnosticsR24AI192252 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Stuart Michael Levitz · 2025 to 2026
$2.4MMechanisms of vaccine immunity against coccidioidomycosisR01AI168370 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRUCE Steven KLEIN · 2023 to 2026
$2.2MMechanisms of Vaccine Immunity against CoccidioidomycosisR56AI168370 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2022 to 2022
$489kNIAID NIH HHS R01 AI035681NIAID NIH HHS R01 AI040996NIAID NIH HHS R01 AI093553NIAID NIH HHS R01 AI168370NIAID NIH HHS R24 AI192252NIAID NIH HHS R37 AI035681NIAID NIH HHS R56 AI168370NIAID NIH HHS U01 AI124299
6 · The paper itselfAbstract
CD4+ T cells that produce IFN-γ (T helper 1 [Th1] cells) chiefly mediate vaccine acquired resistance to fungal infections. However, the key regulators of the development of Th1 cells and acquired resistance to fungi are incompletely understood. Here, we report that Natural Killer Cell Granule Protein (NKG7) acts as an unappreciated regulator inducing anti-fungal Th1 cells to produce IFN-γ and converting plastic Th17 cells into polyfunctional memory Th1 cells.
Indexed as
Fungal VaccinesMycosesTh1 CellsAnimalsInterferon-gammaMiceTh17 CellsFungal VaccinesInterferon-gamma
Identifiers
PMID42536677
PMCPMC13446730
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390