ReviewVirulence2026
Host-Orf virus interactions: A comprehensive review of pathogenesis and immune evasion mechanisms.
Review in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orf virus (ORFV), a zoonotic parapoxvirus, causes contagious ecthyma in small ruminants. It is uniquely characterized by its ability to cause proliferative, self-resolving skin lesions and systematically evade host immunity to cause repeated infections. This review provides an in-depth analysis of ORFV pathogenesis, focusing on viral entry, replication, and lesion development. Furthermore, we highlight the sophisticated immune evasion strategies employed by ORFV that enable it to thrive as a pathogen. By integrating recent molecular and immunological advances, we illustrate how key viral immunomodulatory proteins systematically subvert innate and adaptive host defenses, including interferon pathways, NF-κB signaling, and apoptosis. Deciphering these complex virus-host interactions not only clarifies ORFV's evolutionary success but is also critical for designing effective vaccines and novel therapeutics.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.