In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Ji-Hyung LeeDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-6201-0739 Kiran Kumar NakkaSprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0002-8418-9343 Ryan P CalhounDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0009-0006-2304-6046 Sarah HachmerDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0009-0006-8777-7198 Adity GuptaDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0009-0005-1456-539X Eric ArrezaSprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0009-0008-5243-1765 Lynn A MegeneySprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0002-6824-8569 Patrick SealeDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7119-1615 Roger A GreenbergDepartment of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-1326-8981 F Jeffrey DilworthSprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0002-6265-8102 Foteini MourkiotiDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7119-6640 Funding
Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1MRoles of Chromatin Modification in BRCA1 Dependent DNA RepairR01CA174904 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Roger A Greenberg · 2013 to 2026
$4.8MDNA Double Strand Break Chromatin Alterations and Genome IntegrityR01GM101149 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GREENBERG, ROGER A · 2013 to 2025
$4.0MMetabolic Control of Adipose Tissue Remodeling and FibrosisR01DK123356 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SEALE, PATRICK · 2019 to 2022
$1.9MMolecular mechanisms of telomere function in muscle stem cellsR01AR075914 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MOURKIOTI, FOTEINI · 2020 to 2024
$1.9MMolecular mechanisms of telomere function in muscle cellsR01AR087128 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Foteini Mourkioti · 2026 to 2026
$546kNCI NIH HHS R01 CA174904NIAMS NIH HHS P30 AR069619NIAMS NIH HHS R01 AR075914NIAMS NIH HHS R01 AR087128NIDDK NIH HHS R01 DK123356NIGMS NIH HHS R01 GM101149
6 · The paper itselfAbstract
Stem cell-mediated regeneration is essential for tissue integrity. In skeletal muscle, tissue repair largely depends on muscle stem cells (MuSCs), which undergo dynamic cell-state transitions through making precise fate decisions during regeneration. However, the molecular regulators of cell-state conversion in MuSCs remain unclear. Here, we identify a previously unrecognized, noncanonical role for TRF2 in MuSC biology. TRF2 is dynamically regulated upon injury and required to preserve stem cell identity, support reparative myogenesis, and sustain self-renewal. MuSC-specific TRF2 disruption exacerbates muscular dystrophy pathology in mice, recapitulating key features of human disease. Mechanistically, TRF2 associates with regulatory regions enriched for DNA G-quadruplex-forming sequences at lineage-specific genes, sustaining their expression. These findings establish TRF2 as a pivotal regulator of adult stem cell function and tissue-specific regenerative responses.
Indexed as
Muscle, SkeletalRegenerationStem CellsTelomeric Repeat Binding Protein 2AnimalsCell DifferentiationHumansMiceMuscle DevelopmentTelomeric Repeat Binding Protein 2
Identifiers
PMID42536731
PMCPMC13426418
What Socratic holds
Textmetadata
LicenceCC BY
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