Evidence map›Paper›PMID 42536732›Full record

ArticleScience advances2026

Genetic screening identifies WNT5A/RYK as a determinant of extracellular vesicle fate.

Julia Dancourt, Satish Babu Moparthi, Jeanne Lainé, Shéryl Bui, Jianhang Wang, Maud Chevé, Yingke Xu, Stéphane Vassilopoulos, Grégory Lavieu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julia DancourtINSERM U1334, CNRS UMR8175, Université Paris Cité, NABI, UFR Sciences Fondamentales et Biomédicales, 45 rue des saint Pères, Paris, France.ORCID 0009-0007-5228-960X
Satish Babu MoparthiSorbonne Université, INSERM, Institute of Myology, Centre of Research in Myology, UMRS 974, Paris, France.ORCID 0000-0001-7493-3848
Jeanne LainéSorbonne Université, INSERM, Institute of Myology, Centre of Research in Myology, UMRS 974, Paris, France.
Shéryl BuiINSERM U1334, CNRS UMR8175, Université Paris Cité, NABI, UFR Sciences Fondamentales et Biomédicales, 45 rue des saint Pères, Paris, France.ORCID 0000-0002-7460-6676
Jianhang WangDepartment of Biomedical Engineering, MOE Key Laboratory of Biomedical Engineering, State Key Laboratory of Extreme Photonics and Instrumentation, Zhejiang Provincial Key Laboratory of Intelligent Sensing and Advanced Medical Instrument, Zhejiang University, Hangzhou, Zhejiang 310027, China.
Maud ChevéINSERM U1334, CNRS UMR8175, Université Paris Cité, NABI, UFR Sciences Fondamentales et Biomédicales, 45 rue des saint Pères, Paris, France.
Yingke XuDepartment of Biomedical Engineering, MOE Key Laboratory of Biomedical Engineering, State Key Laboratory of Extreme Photonics and Instrumentation, Zhejiang Provincial Key Laboratory of Intelligent Sensing and Advanced Medical Instrument, Zhejiang University, Hangzhou, Zhejiang 310027, China.ORCID 0000-0002-8317-0608
Stéphane VassilopoulosSorbonne Université, INSERM, Institute of Myology, Centre of Research in Myology, UMRS 974, Paris, France.ORCID 0000-0003-0172-330X
Grégory LavieuINSERM U1334, CNRS UMR8175, Université Paris Cité, NABI, UFR Sciences Fondamentales et Biomédicales, 45 rue des saint Pères, Paris, France.ORCID 0000-0001-8653-8650

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are natural mediators of intercellular communication through the transfer of cytoplasmic material from donor to recipient cells. The molecular mechanisms governing EV uptake and cargo delivery in recipient cells remain largely elusive. To address this gap, we performed a genetic screening interrogating 300 genes of the dynamic surfaceome for their involvement in EV uptake. Activators found in the screening establish a previously unknown connection between EV uptake and Wnt pathways. We then observed that, unlike WNT-naïve EVs that are primarily trafficked to lysosomes in recipient cells, WNT5A-bearing EVs linger in early endocytic structures. This rerouting is dependent on the expression of RYK, an established co-receptor for WNT5A. Our results depict a mechanism underlying EV functional heterogeneity as well as reveal a potential regulation system for noncanonical WNT signaling.

Indexed as

Extracellular VesiclesWnt-5a ProteinAnimalsGenetic TestingHumansLysosomesWnt Signaling PathwayWnt-5a ProteinWNT5A protein, human

Identifiers

PMID42536732
PMCPMC13426412

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.