Evidence map›Paper›PMID 42536746›Full record

ArticleScience advances2026

Cohesin and NuRD antagonistically drive alternative neuronal fates via PLZF transcription factors.

Dongyeop Lee, Takashi Hirose, H Robert Horvitz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Dongyeop LeeHoward Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-8973-5430
Takashi HiroseHoward Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
H Robert HorvitzHoward Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-9964-9613

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9M
Genetic Analysis of Nematode Egg Laying and Co-regulated Behavioral SystemsR01GM024663 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HORVITZ, H ROBERT · 1985 to 2025
$10.1M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NCI NIH HHS P30 CA014051NIGMS NIH HHS R01 GM024663NIH HHS P40 OD010440
6 · The paper itself

Abstract

Diverse genetic and epigenetic factors cooperate to specify cellular fates during development. Establishing these fates is especially critical in the nervous system, which comprises diverse neuronal cell types. How genomic architecture interfaces with epigenetic regulators to drive transcriptional programs underlying neuronal fates remains poorly understood. Here, we show that cohesin, a protein complex that shapes genomic architecture, promotes GABAergic fate specification in a subset of neurons in the nematode

Indexed as

Caenorhabditis elegans ProteinsCell Cycle ProteinsChromosomal Proteins, Non-HistoneMi-2 Nucleosome Remodeling and Deacetylase ComplexNeuronsPromyelocytic Leukemia Zinc Finger ProteinTranscription FactorsAnimalsCaenorhabditis elegansCell DifferentiationCohesinsEpigenesis, GeneticGABAergic NeuronsGene Expression Regulation, DevelopmentalCaenorhabditis elegans ProteinsCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsMi-2 Nucleosome Remodeling and Deacetylase ComplexPromyelocytic Leukemia Zinc Finger ProteinTranscription Factors

Identifiers

PMID42536746
PMCPMC13426411

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.