Evidence map›Paper›PMID 42537668›Full record

ArticleBiofabrication2026

Modeling the synovium on a chip for studying the interactions between lymphatic vasculature and synoviocytes in rheumatoid arthritis.

Samantha E Kraus, Issahy Cano, Soo Jin Kim, Esak Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biofabrication, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samantha E KrausNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, United States of America.ORCID 0000-0003-2710-1656
Issahy CanoDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States of America.ORCID 0000-0001-9994-149X
Soo Jin KimNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, United States of America.
Esak LeeNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, United States of America.ORCID 0000-0002-5328-6677

Funding

Regulation of Lymphatic Endothelial Cell Junction and DrainageR01HL165135 · NHLBI · CORNELL UNIVERSITY · PI Esak Lee · 2022 to 2026
$2.5M
Tissue-Engineered Models of Lymphatic Drainage in Breast CancerR01CA279560 · NCI · CORNELL UNIVERSITY · PI Esak Lee · 2023 to 2026
$1.6M
High-throughput nanoIEA-based Assay for Screening Immune Cell-Vascular InteractionsR21AI168886 · NIAID · CORNELL UNIVERSITY · PI KIM, DEOK-HO, LEE, ESAK · 2023 to 2024
$450k
NCI NIH HHS R01 CA279560NHLBI NIH HHS R01 HL165135NIAID NIH HHS R21 AI168886
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that afflicts the synovial lining of joints and manifests in reduced range of motion, pain, swelling, and numerous other complications with no effective cure. In recent years, attention has shifted toward eradicating the source of synovial autoimmunity and inflammation, with a key focus on the synovial-draining lymphatics. However, very few

Indexed as

Arthritis, RheumatoidLab-On-A-Chip DevicesLymphatic VesselsModels, BiologicalSynovial MembraneSynoviocytesAnimalsEndothelial CellsHumansMiceMicrophysiological Systemslymphaticsmicrofluidic chiprheumatoid arthritissynovium

Identifiers

PMID42537668
PMCPMC13469983

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.