Evidence map›Paper›PMID 42538433›Full record

ArticleNature structural & molecular biology2026

Factors modulating the assembly of human β

Florian M Wilhelm, Kristyna Pluhackova, John Janetzko, Matthieu Masureel, Erin Marsh, Jesse Hudspeth, Wenzel Gaßner, Gebhard F X Schertler, Brian K Kobilka, Daniel J Müller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature structural & molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Florian M Wilhelm *Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.ORCID http://orcid.org/0000-0001-9844-3536
Kristyna Pluhackova *Stuttgart Center for Simulation Science, Cluster of Excellence EXC 2075, University of Stuttgart, Stuttgart, Germany.ORCID http://orcid.org/0000-0002-7498-6584
John JanetzkoDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1604-2515
Matthieu MasureelDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Erin MarshDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0009-0002-9078-5288
Jesse HudspethDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-7557-8964
Wenzel GaßnerStuttgart Center for Simulation Science, Cluster of Excellence EXC 2075, University of Stuttgart, Stuttgart, Germany.
Gebhard F X SchertlerPaul Scherrer Institute PSI, Villigen, Switzerland.ORCID http://orcid.org/0000-0002-5846-6810
Brian K KobilkaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5958-3990
Daniel J MüllerDepartment of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland. daniel.mueller@bsse.ethz.ch.ORCID http://orcid.org/0000-0003-3075-0665

Funding

Investigating the molecular details of assembly, disassembly and trafficking of GPCR-arrestin complexesR00GM147609 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI John Janetzko · 2025 to 2026
$498k
Investigating the molecular details of assembly, disassembly and trafficking of GPCR-arrestin complexesK99GM147609 · NIGMS · STANFORD UNIVERSITY · PI JANETZKO, JOHN · 2022 to 2023
$225k
NIGMS NIH HHS K99 GM147609NIGMS NIH HHS R00 GM147609
6 · The paper itself

Abstract

β-arrestins, pivotal regulators of G protein-coupled receptor (GPCR) signaling, assemble with hundreds of GPCRs. How this assembly rises to functionally distinct complexes in which β-arrestin engages the GPCR tail, core or both, remains a central question. Here employing single-molecule force spectroscopy and molecular dynamics simulations, we monitor assembly of β

Indexed as

beta-Arrestin 2beta-ArrestinsReceptors, Adrenergic, beta-2HumansMolecular Dynamics SimulationPhosphatidylinositol 4,5-DiphosphatePhospholipidsPhosphorylationProtein BindingSignal Transductionbeta-Arrestin 2beta-ArrestinsPhosphatidylinositol 4,5-DiphosphatePhospholipidsReceptors, Adrenergic, beta-2

Identifiers

PMID42538433
PMCPMC13468150

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.