Evidence map›Paper›PMID 42538519›Full record

ReviewOphthalmology and therapy2026

Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care.

Luca Buzzonetti, Cosimo Mazzotta, Michele Iester, Mikk Pauklin, Daniel Boehringer, Reda Zemaitiene, Martino Vannucchi, Lidia Cocho, Pavel Studeny, Amélie Gavard and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Ophthalmology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Luca BuzzonettiERN-EYE, Ophthalmology Unit, Bambino Gesù IRCCS Children's Hospital, Piazza Sant'Onofrio 4, 00165, Rome, Italy. luca.buzzonetti@opbg.net.ORCID http://orcid.org/0000-0002-3200-3260
Cosimo MazzottaFaculty of Medicine and Surgery, Ophthalmology Unit, Kore University of Enna (UKE), Enna, Italy.ORCID http://orcid.org/0000-0002-1829-9288
Michele IesterEye Clinic, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Mikk PauklinERN-EYE, Eye Clinic, Tartu University Hospital, Tartu, Estonia.ORCID http://orcid.org/0009-0008-9282-0503
Daniel BoehringerEye Center, University Hospital Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-9042-0508
Reda ZemaitieneERN-EYE, Department of Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania.ORCID http://orcid.org/0000-0003-0757-1589
Martino VannucchiERN-EYE, Pediatric Ophthalmology Unit, Meyer Children's Hospital IRCCS, University of Florence, Florence, Italy.
Lidia CochoERN-EYE, Department of Ophthalmology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Pavel StudenyDepartment of Ophthalmology, University Hospital Královské Vinohrady and 3rd Faculty of Medicine, Charles University, Prague, Czech Republic.ORCID http://orcid.org/0000-0003-1279-4074
Amélie GavardERN-EYE Coordination Center, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.ORCID http://orcid.org/0009-0008-4957-6082
Cristina MonterossoDepartment of Ophthalmology, Ospedale dell'Angelo, Mestre, VE, Italy.
Dominique Bremond-GignacERN-EYE, Ophthalmology Department, Necker-Enfants Malades University Hospital, Paris Cité University, OPHTARA Center, AP-HP, Paris, France.ORCID http://orcid.org/0000-0002-3563-5482
Manca Tekavcic PompeERN-EYE, Eye Hospital, UMC Ljubljana, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0003-3730-0229
Jean-Louis BourgesINSERM, UMRS1138, Team 17, From Physiopathology of Ocular Diseases to Clinical Development, Centre de Recherche des Cordeliers, Université Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-7016-9819
Petra LiskovaERN-EYE, Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.ORCID http://orcid.org/0000-0001-7834-8486

Funding

Directorate-General for Health and Food Safety 101085439Directorate-General for Health and Food Safety ERN-EYE 22-23European Health and Digital Executive Agency 84498European Health and Digital Executive Agency Project 101155859 - ERN-EYE 2023-2027
6 · The paper itself

Abstract

This clinical consensus statement, developed through the European Reference Network for Rare Eye Diseases (ERN-EYE), provides recommendations for the diagnosis, monitoring and management of paediatric keratoconus. Paediatric keratoconus is a corneal ectasia that typically presents during childhood or adolescence, often advancing rapidly and significantly affecting visual development. Despite its impact, standardised paediatric-specific guidelines are lacking. A multidisciplinary panel of experts from across Europe contributed to this statement through a structured Delphi process. The consensus reviews the current understanding of the physiopathology, diagnostic criteria, risk factors and classification systems of paediatric keratoconus. It outlines strategies for early detection and monitoring, emphasises the role of patient and family education and presents current treatment approaches, with specific recommendations for paediatric care. The aim of this document is to guide ophthalmologists, paediatricians and associated professionals in delivering timely and appropriate care, improving outcomes for children with keratoconus across Europe.

Indexed as

Cross-linkingGuidelinesKeratoconusKeratoplastyPaediatric keratoconusRare diseases

Identifiers

PMID42538519

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.