ArticleAmerican journal of physiology. Cell physiology2026
Maternal obesity disrupts trophoblast differentiation and causes female-specific labyrinth defects in the mouse placenta.
Li-Wei Chen, Zhongyun Kou, Md Nazmul Hossain, Chaeyoung Shin, Sharmeen Islam, Xinrui Li, Jeanene Marie de Avila, Min Du
Abstract read
In one paragraphArticle in American journal of physiology. Cell physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Li-Wei ChenNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, Washington, United States.ORCID 0000-0003-2878-8613 Zhongyun KouNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, Washington, United States.ORCID 0000-0003-2369-049X Md Nazmul HossainNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, Washington, United States.
Chaeyoung ShinNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, Washington, United States.ORCID 0000-0002-9030-1362 Sharmeen IslamNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, Washington, United States.
Xinrui LiNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, Washington, United States.ORCID 0009-0002-7590-1543 Jeanene Marie de AvilaNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, Washington, United States.
Min DuNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, Washington, United States.ORCID 0000-0002-7232-072X Funding
Maternal obesity, AMPK and fetal brown adipogenesisR01HD067449 · NICHD · WASHINGTON STATE UNIVERSITY · PI MIN DU · 2010 to 2026
$4.6MHHS | National Institutes of Health (NIH) R01HD067449NICHD NIH HHS R01 HD067449
6 · The paper itselfAbstract
Maternal obesity (MO) alters the intrauterine environment and increases the risk of a variety of developmental outcomes; however, the effects on placental cell population and development remain unclear. In this study, we investigated the impact of MO on placental cellular composition, development, and morphology in C57BL/6J mice fed a control or high-fat diet. Single-cell RNA sequencing of
Indexed as
Cell DifferentiationObesityPlacentaPregnancy in ObesityTrophoblastsAnimalsBasic Helix-Loop-Helix ProteinsDevelopmental Origins of Health and DiseaseDiet, High-FatFemaleGene Expression Regulation, DevelopmentalMaleMiceMice, Inbred C57BLPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPlacentationBasic Helix-Loop-Helix ProteinsHand1 protein, mousePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseProlactinTfap2c protein, mouseTranscription Factor AP-2maternal obesityoxidative metabolismplacentaprolactintrophoblast
Identifiers
PMID42538850
PMCPMC13499971
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