Evidence map›Paper›PMID 42539099›Full record

ArticleResearch square2026

Age at menopause,

Madeline Wood Alexander, Alexander J Nyman, Kaitlin B Casaletto, Rowan Saloner, Katie L Vandeloo, Tallinn F L Splinter, Walter Swardfager, Julie Ottoy, Mario Masellis, Liisa A M Galea and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Madeline Wood AlexanderHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0003-4598-0201
Alexander J NymanHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Kaitlin B CasalettoFein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Rowan SalonerFein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.ORCID 0000-0002-1351-6183
Katie L VandelooHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Tallinn F L SplinterHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Walter SwardfagerHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0002-0030-8908
Julie OttoyHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Mario MasellisHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Liisa A M GaleaDepartment of Pharmacology & Toxicology, University of Toronto, Ontario, Canada.
Sandra E BlackHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Gillian EinsteinRotman Research Institute, Baycrest Hospital, University of Toronto, Toronto, Ontario, Canada.
Marisa N DenkingerBanner Sun Health Research Institute, Sun City, AZ, USA.
Nicholas J AshtonBanner Sun Health Research Institute, Sun City, AZ, USA.
Jessica Z K CaldwellWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Sterling C JohnsonWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-8501-545X
Zoe ArvanitakisRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Jennifer S RabinHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0003-4754-2221

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
API A4 Alzheimer's Prevention TrialR01AG058468 · NIA · BANNER HEALTH · PI AISEN, PAUL S., ALEXANDER, ROBERT C · 2018 to 2025
$31.9M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI ALIREZA ATRI · 2021 to 2026
$24.9M
Rush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7M
Wisconsin Registry for Alzheimer's PreventionRF1AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, STERLING C · 2018 to 2018
$18.8M
Risk Factors for Cognitive Decline in African-AmericansR01AG022018 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2004 to 2025
$18.2M
NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG058468NIA NIH HHS RF1 AG027161
6 · The paper itself

Abstract

Importance: Objective: To examine whether age at menopause modifies the association of Design setting and participants: Data were analyzed from postmenopausal women free from known dementia at study entry in two longitudinal datasets: (1) the harmonized data from the Religious Orders Study, Rush Memory and Aging Project, and Minority Aging Research Study (ROS/MAP/MARS), and (2) the Wisconsin Registry for Alzheimer's Prevention (WRAP). Data were collected between 1994-2025. Main outcomes and measures: In both datasets, neuropsychological tests assessed longitudinal memory performance, and MRI quantified cortical thickness and brain volume in AD vulnerable regions. In WRAP, which included Results: The study included 2,625 women in ROS/MAP/MARS (mean [ Conclusions and relevance: Earlier menopause strengthened the associations between

Identifiers

PMID42539099
PMCPMC13419616

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.