Evidence map›Paper›PMID 42539318›Full record

ArticlebioRxiv : the preprint server for biology2026

Ribonucleotide Reductase Inhibition Overcomes FLT3 Inhibitor Resistance in Acute Myeloid Leukemia.

Zhen Tian, Xiaoyu Wei, Srinivas Chatla, Yang Liu, Dongwook Kim, Yahui Li, Peng Wang, Yun Liao, Xiaolei Liu, Dan Yang and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Zhen TianCoriell Institute for Medical Research, Camden, NJ, USA.
Xiaoyu WeiCoriell Institute for Medical Research, Camden, NJ, USA.
Srinivas ChatlaFels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Yang LiuCoriell Institute for Medical Research, Camden, NJ, USA.
Dongwook KimCoriell Institute for Medical Research, Camden, NJ, USA.
Yahui LiDepartment of Surgery, Cooper University Health Care, Camden, NJ, USA.
Peng WangCoriell Institute for Medical Research, Camden, NJ, USA.
Yun LiaoCoriell Institute for Medical Research, Camden, NJ, USA.
Xiaolei LiuDivision of Hematology/Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Dan YangCoriell Institute for Medical Research, Camden, NJ, USA.
Stacia OctavianiCoriell Institute for Medical Research, Camden, NJ, USA.
Gui MaGenetic and Epigenetic Mechanism Program, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
Anthony PompettiCoriell Institute for Medical Research, Camden, NJ, USA.
Gennaro CalendoCoriell Institute for Medical Research, Camden, NJ, USA.ORCID 0000-0002-4510-5530
Martin P KeoughDivision of Hematology/Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Wei XuGenetic and Epigenetic Mechanism Program, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
Jing ZhangMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Hong ZhengDivision of Hematology/Oncology, Penn State Cancer Institute, Penn State University College of Medicine, Hershey, PA, USA.
Elliot StieglitzDepartment of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, CA, USA.
Catherine SmithDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.
Jian HuangCoriell Institute for Medical Research, Camden, NJ, USA.ORCID 0000-0002-1649-0038

Funding

The role of TCOF1 in germline predisposition to and in leukemic transformation of chronic myelomonocytic leukemiaR01CA152108 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Jing Zhang · 2011 to 2026
$5.4M
Explore the signaling mechanisms of acquired resistance to tyrosine kinase inhibitors in AMLR01CA255221 · NCI · CORIELL INSTITUTE FOR MEDICAL RESEARCH · PI HUANG, JIAN · 2021 to 2025
$2.0M
NCI NIH HHS R01 CA152108NCI NIH HHS R01 CA255221
6 · The paper itself

Abstract

Internal tandem duplication mutations in

Identifiers

PMID42539318
PMCPMC13420411

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.