ReviewFrontiers in immunology2026
Caspases and programmed cell death in sepsis: mechanisms, pathophysiology, and therapeutic targets.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis represents a critical medical condition characterized by organ impairment resulting from an uncontrolled systemic reaction to pathogenic infection, posing substantial difficulties in intensive care management. As a key pathological mechanism, programmed cell death (PCD) critically contributes to sepsis development, and caspases act as the central molecular hub governing multiple PCD modalities, including apoptosis, necroptosis, pyroptosis, and PANoptosis. In this manuscript, we review the classification and structural features of caspases, illustrate their molecular mechanisms in regulating the four PCD pathways, and clarify the dual pathological roles of these PCD forms in sepsis-induced immune dysregulation and organ damage. We also summarize therapeutic strategies targeting caspases and provide a theoretical basis for developing novel targeted treatments for sepsis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.