← Metformin × glycemic control

SynthesisFrontiers in endocrinology2026

Efficacy of Gegen Qinlian decoction plus metformin for type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.

Hongyang He et al.PubMed ↗Full text ↗Publisher ↗

  • GQD plus metforminno clear effectLower fasting blood sugar, lower 2hPG, no clear effect on long-term blood sugar.Nothing cleared the noise.

What the trial testedas reported · 725 people · 2026

Not counted

Probably lowered fasting blood sugar

−1.08−1.71 to −0.44

GQD plus metformin vs metformin alone

As reported

difference −1.08, 95% CI −1.71 to −0.44 · the paper's word: FPG

Not counted

Probably lowered 2hPG

−1.73−3.05 to −0.42

GQD plus metformin vs metformin alone

As reported

difference −1.73, 95% CI −3.05 to −0.42

Range includes no effect

No clear effect on long-term blood sugar

−1.92−4.43 to +0.59

GQD plus metformin vs metformin alone

As reported

difference −1.92, 95% CI −4.43 to 0.59 · the paper's word: HbA1c

Who was studied, and how

725people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

GQD plus metformin
metformin alone

Probably lowered fasting blood sugar−1.08

Probably lowered 2hPG−1.73

No clear effect on long-term blood sugar−1.92

randomised

the abstract, start to end

… reductions were observed for FPG (MD = -1.08, 95% CI: -1.71 to -0.44, P = 0.0009) and 2hPG (MD = -1.73, 95% CI: -3.05 to -0.42, P = …

… metformin alone (mean difference [MD] = -1.92, 95% confidence interval [CI]: …

← favours treatmentfavours comparator →
could be chance
FPGGQD plus metformin vs metformin alone
−1.08−1.71 to −0.44
2hPGGQD plus metformin vs metformin alone
−1.73−3.05 to −0.42
HbA1cGQD plus metformin vs metformin alone
−1.92−4.43 to 0.59
MetforminGlycemic control
1 / 4

Not cited yet

Full record →Abstract, authors, funding and every citing paper · PMID 42539441