Evidence map›Paper›PMID 42539534›Full record

ArticleFrontiers in microbiology2026

Heng Zhang, Hua Ni, Mengqi Peng, Tian Chen, Lu Ge, Xueying Zhang, Kai Tian, Yi Sun

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Heng Zhang *Department of Dermatology, Hubei Provincial Clinical Research Center for Diagnosis and Therapeutics of Pathogenic Fungal Infection, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, China.
Hua Ni *Department of Nephrology, Hubei Provincial Clinical Research Center for Diagnosis and Therapeutics of Pathogenic Fungal Infection, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, China.
Mengqi Peng *Department of Clinical Medicine, Yangtze University, Jingzhou, Hubei, China.
Tian ChenDepartment of Clinical Medicine, Yangtze University, Jingzhou, Hubei, China.
Lu GeDepartment of Clinical Medicine, Yangtze University, Jingzhou, Hubei, China.
Xueying ZhangDepartment of Clinical Medicine, Yangtze University, Jingzhou, Hubei, China.
Kai TianDepartment of Clinical Medicine, Yangtze University, Jingzhou, Hubei, China.
Yi SunDepartment of Dermatology, Hubei Provincial Clinical Research Center for Diagnosis and Therapeutics of Pathogenic Fungal Infection, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dematiaceous fungal infections are frequently encountered in clinical practice with no unified treatment. Drug combination reduces drug resistance, and repurposed clinical drugs as synergists show promise in aiding azoles against phaeohyphomycosis. Objective: To investigate the synergistic antifungal effects of docetaxel (DTX) in combination with azoles against dematiaceous fungi and Methods: CLSI M38-A2 microbroth dilution method was used to detect fractional inhibitory concentration index of DTX with posaconazole (POS), itraconazole (ITC), voriconazole (VOR), and isavuconazole (ISA) against 43 fungi (including 24 strains of Results: DTX alone had no antifungal activity. 30/43 (69.8%) strains showed synergy with POS (87.5% Conclusion: The combined scheme of DTX and POS can significantly reduce the minimum inhibitory concentration of POS and show synergistic antifungal activity, especially significant against

Indexed as

antifungal activityAspergillus nigerazolesdematiaceous fungidocetaxelExophiala dermatitidissynergism

Identifiers

PMID42539534
PMCPMC13423856

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.