ArticleAdvances in drug and alcohol research2026
Cholesterol and docosahexaenoic acid likely protect against alcohol-induced constriction of cerebral arteries via a common pathway.
Article in Advances in drug and alcohol research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Binge alcohol drinking is significantly associated with an increased risk of cerebrovascular dysfunction. Within cerebral artery smooth muscle, alcohol inhibits calcium- and voltage-gated potassium (BK) channels of large-conductance, leading to cerebrovascular constriction. Administration of high-cholesterol diet or docosahexaenoic acid (DHA) supplementation independently protects against alcohol-induced constriction of cerebral arteries. However, whether these interventions act additively or through a shared mechanism(s) remains unclear. Here, we examined the combined effects of cholesterol and DHA dietary supplementation
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