Evidence map›Paper›PMID 42539585›Full record

ArticleFrontiers in immunology2026

Karel F A Van Damme, Pieter Hertens, Dorine Sichien, Katrien Van der Borght, Justine Van Moorleghem, Sofie De Prijck, Alex Klarenbeek, Els Louagie, Inés Lammens, Stijn Vanhee and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Karel F A Van DammeLaboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Pieter HertensLaboratory of Cellular and Molecular (Patho)physiology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Dorine SichienLaboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Katrien Van der BorghtLaboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Justine Van MoorleghemLaboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Sofie De PrijckLaboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Alex KlarenbeekLaboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Els Louagieargenx, Ghent, Belgium.
Inés LammensLaboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Stijn VanheeLaboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Christian VanhoveIBiTech-Medisip-Infinity Lab, Ghent University, Ghent, Belgium.
Pieter De BleserDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Steven Van LaeckeRenal Division, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium.
Amélie DendoovenDivision of Pathology, University Hospital Ghent, Ghent, Belgium.
Hamida HammadLaboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Lars VereeckeDepartment of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Dirk ElewautDepartment of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Geert van LooLaboratory of Cellular and Molecular (Patho)physiology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Bart N LambrechtLaboratory of Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feedback mechanisms regulate immune activation and prevent excessive tissue damage. TNFAIP3, also known as A20, serves as a crucial brake on inflammation, and mutations or haploinsufficiency of this gene are linked to diseases characterized by inappropriate inflammation. In this study, we document highly conserved patterns of cell type-specific gene expression, regulation, and induction of

Indexed as

Immunity, InnateInflammationTumor Necrosis Factor alpha-Induced Protein 3AnimalsAutoantibodiesB-LymphocytesDisease Models, AnimalHumansMiceMice, KnockoutMice, TransgenicAutoantibodiesTnfaip3 protein, mouseTumor Necrosis Factor alpha-Induced Protein 3A20B cellsgerm-freeinnate immunitylupusTNFAIP3

Identifiers

PMID42539585
PMCPMC13423863

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.