ReviewFrontiers in immunology2026
B7-H3 (CD276): an actionable therapeutic target and prognostic biomarker across human malignancies.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Immune checkpoint protein B7-H3 (CD276) has garnered increasing attention as a cancer immunotherapy target. Despite the absence of a definitively identified receptor, B7-H3 is implicated in multiple mechanisms of tumor progression. As a cancer biomarker, it is overexpressed in numerous cancer types and is often associated with poor prognosis. B7-H3 is currently the target of numerous immunotherapeutic strategies, and clinical trials are underway in various cancer types. This review provides an updated summary of the current body of knowledge regarding immune checkpoint protein B7-H3 and cancer therapies targeting it, highlighting its demonstrated promise as a cancer immunotherapy target, the need for further investigation into the regulation and mechanisms of B7-H3 and its associated pathways, and therapeutic progress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.