ArticleFundamental research2026
A novel integrated ESID strategy of critical property-flavor quality attributes of Huangqi Shengmai Yin.
Article in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Application of biosensors in research of traditional Chinese medicine: a systematic review.Chinese medicine · 2026Review
- Artificial Intelligence-Enabled Intelligent Sensory Systems for Quality Evaluation of Traditional Chinese Medicine: A Review of Electronic Nose, Electronic Tongue, and Machine Vision Approaches.Molecules (Basel, Switzerland) · 2026Review
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Authors and funding
17 authors.
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Abstract
There is still a gap between traditional Chinese medicine (TCM) and Western medicine, and it is crucial to build a bridge between them. In this study, taking Huangqi Shengmai Yin as a demonstration, we proposed a novel integrated efficacy-sweetness information discovery (ESID) strategy. Firstly, it was inferred that Huangqi Shengmai Yin possessed the attribute of "sweet", and its sweetness level was determined by intelligent sensory technology. Secondly, the potential property and flavor substances of Huangqi Shengmai Yin were screened based on our T1R2/T1R3-HEMT biosensor combined with UPLC-MS analysis. Finally, the efficacy of the substances was validated through in vitro and in vivo experiments. The results indicated that the sensory taste of Huangqi Shengmai Yin was perceived as sweet, with the sweetness level classified as "slightly sweet". Five potential property and flavor substances of Huangqi Shengmai Yin were discovered, including calycosin, calycosin-7-O-β-d-glucoside, atractylenolide I, ruscogenin and schisantherin A. Surprisingly, it was confirmed that these attributes had strong binding abilities with T1R2 and T1R3, with dissociation constants less than 10
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