ArticleBiology methods & protocols2026
Semaglutide use linked to lower COVID-19 and influenza severity with better renal outcomes after pandemic or seasonal infection.
Article in Biology methods & protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Respiratory viral infections continue to impose a large burden of hospitalization, organ failure and death, particularly among older adults and people with cardiometabolic disease. Whether prior semaglutide exposure is associated with lower post-infection severity across distinct respiratory viruses remains uncertain. We analyzed de-identified longitudinal electronic health record data from a federated U.S. network spanning more than 29 million patients. Adults with documented COVID-19 or influenza infection were classified by pre-infection semaglutide use versus metformin use without prior GLP-1 receptor agonist exposure and one-to-one propensity matched on demographics, BMI, HbA1c, vaccination status, prior infection status, antiviral use, healthcare utilization extent, and baseline comorbidities, yielding matched cohorts of
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