Evidence map›Paper›PMID 42540173›Full record

ArticleACS omega2026

Molecular Dynamics and Free Energy Calculations Predict Binding Mode and Affinity Determinants of Specialized Pro-Resolving Mediators at GPR101.

Daniel Haga Hasselstrøm, Majd Awad, Trond Vidar Hansen, Osman Gani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel Haga HasselstrømDepartment of Pharmacy, Section for Pharmaceutical Chemistry, University of Oslo, 0316 Oslo, Norway.ORCID https://orcid.org/0009-0003-9154-335X
Majd AwadDepartment of Pharmacy, Section for Pharmaceutical Chemistry, University of Oslo, 0316 Oslo, Norway.
Trond Vidar HansenDepartment of Pharmacy, Section for Pharmaceutical Chemistry, University of Oslo, 0316 Oslo, Norway.ORCID https://orcid.org/0000-0001-5239-9920
Osman GaniDepartment of Pharmacy, Section for Pharmaceutical Chemistry, University of Oslo, 0316 Oslo, Norway.ORCID https://orcid.org/0009-0000-0515-2781

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GPR101 is an orphan G protein-coupled receptor (GPCR) with unusually high constitutive activity and has recently emerged as a target for specialized pro-resolving mediators (SPMs), endogenous lipids that actively terminate inflammation and promote tissue repair. Given the therapeutic relevance of pro-resolution signaling in chronic pain and inflammatory disorders, understanding how SPMs engage GPR101 is of great significance. Although cryo-EM structures suggest an occluded orthosteric cavity, SPMs such as RvD5

Identifiers

PMID42540173
PMCPMC13425295

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.