Evidence map›Paper›PMID 42540299›Full record

ArticleBioactive materials2026

Cells perceive the distribution differences of adhesion ligands and consequently establish cellular polarization to regulate osteogenic differentiation.

Jinsheng Li, Ming Yang, Guowen Duan, Jianhao Huang, Tao Shen, Jie Cui, Keke Huang, Qiting Ge, Liming Yang, Jingyi Sheng and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jinsheng LiDivision of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210008, PR China.
Ming YangNanjing Research Center for Biomedical Electron Microscopy (NRC-BEM), Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210093, PR China.
Guowen DuanInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China.
Jianhao HuangDepartment of Orthopedics, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210002, PR China.
Tao ShenDivision of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210008, PR China.
Jie CuiCollege of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, Jiangsu, 210016, PR China.
Keke HuangDivision of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210008, PR China.
Qiting GeDivision of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210008, PR China.
Liming YangNanjing Research Center for Biomedical Electron Microscopy (NRC-BEM), Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210093, PR China.
Jingyi ShengJiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, PR China.
Jie WengInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China.
Tailin GuoInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China.
Zhihong XuDivision of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210008, PR China.
Jizi LiuNanjing Research Center for Biomedical Electron Microscopy (NRC-BEM), Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210093, PR China.
Ning GuNanjing Research Center for Biomedical Electron Microscopy (NRC-BEM), Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210093, PR China.
Qing JiangDivision of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210008, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engineering implant topography has emerged as a promising strategy to promote bone regeneration in complex fractures and large bone defects. Among such topographies, TiO

Indexed as

Adhesive ligand distributionCellular polarizationFocal adhesion maturationNanotube-based topographyOsteogenic mechanotransduction

Identifiers

PMID42540299
PMCPMC13425717

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.