Evidence map›Paper›PMID 42540416›Full record

ReviewBioactive materials2026

Hydrogel coatings for titanium implants: From smart stimuli-responsive strategies to multimodal bone regeneration.

Aoao Wang, Zebin Gui, Li Ruan, Chaofeng Hu, Phuong Vy Tran, You Zhou, Jiao Jiao Li, Jiajia Xue, Rui Shi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aoao WangNational Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, PR China.
Zebin GuiNational Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, PR China.
Li RuanBeijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Chaofeng HuNational Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, PR China.
Phuong Vy TranSchool of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney, Sydney, NSW, 2007, Australia.
You ZhouNational Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, PR China.
Jiao Jiao LiSchool of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney, Sydney, NSW, 2007, Australia.
Jiajia XueBeijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Rui ShiNational Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Titanium implants are widely used in orthopedic surgery due to their excellent biocompatibility and mechanical properties. However, their long-term clinical success is often limited by complications such as postoperative infection, chronic inflammation, and inadequate osseointegration. In recent years, hydrogels have been extensively explored for tissue regeneration because of their biological activity and functional versatility. One emerging application is the surface modification of titanium implants, in which hydrogel coatings can be engineered to improve implant adaptability and osseointegration under complex pathological conditions. This review summarizes the classification, fabrication methods, stimuli-responsive features, and emerging bone-regenerative applications of hydrogel coatings on titanium implants. We also discuss the prospects and challenges of functionalized hydrogel coatings for titanium implants in clinical translation. By examining the latest advances in this rapidly evolving research area, the review aims to catalyze innovation in implant-based bone repair and therapeutic applications.

Indexed as

Bone regenerationHydrogel coatingOsseointegrationStimuli-responsive characteristicsTitanium implants

Identifiers

PMID42540416
PMCPMC13425725

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.