ArticleArchives of medical science : AMS2026
Serum total bile acids are associated with coronary artery calcification as assessed by non-gated chest computed tomography: a multicenter study.
Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Coronary artery calcification (CAC) is a risk factor for cardiovascular disease (CVD). The association between serum total bile acid (TBA) concentration and CAC has not been investigated, even though bile acid may act as a mediator between gut microbiota and CVD. We examined this relationship in a general Chinese population. Material and methods: This cross-sectional study included 2133 people who underwent computed tomography (CT) scans for lung cancer screening between 2018 and 2020. Information on medical history, laboratory test results, and demographics was collected from medical records. CAC was assessed on non-gated chest CT images. Multivariable logistic regression analysis and restricted triple spline analysis were applied to examine the correlation between TBA and CAC risk. Results: CACs were detected in 426 of 2133 participants. Participants with higher TBA concentrations had a considerably higher prevalence of CAC (33.4% in the fourth quartile and 11.5% in the first quartile, Conclusions: A substantial and positive correlation was found between elevated TBA and CAC. The causal relationship between TBA and CAC risk should be investigated in longitudinal studies.
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