ReviewCureus2026
Emerging Neurovascular Interventions for the Prevention of Cerebral Vasospasm and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aneurysmal subarachnoid hemorrhage remains a major cause of neurological morbidity and mortality, with delayed cerebral ischemia and cerebral vasospasm representing important contributors to secondary brain injury and unfavorable functional recovery. Although conventional management strategies such as nimodipine administration, hemodynamic augmentation, and endovascular rescue therapy remain central to clinical practice, growing evidence suggests that delayed cerebral ischemia is a multifactorial neurovascular process extending beyond isolated large vessel vasospasm. This systematic review evaluated emerging neurovascular interventions for the prevention and management of cerebral vasospasm and delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. A comprehensive literature search was conducted across PubMed/MEDLINE, Scopus, and Web of Science databases for studies published between January 2020 and February 2026 in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Nine studies met the eligibility criteria and were included in the qualitative synthesis. The included interventions encompassed endothelin receptor antagonists, localized nicardipine release implants, intra-arterial nimodipine infusion, microcirculatory targeted pharmacologic therapies, anti-inflammatory neuroprotective agents, and autonomic neuromodulatory approaches. Several interventions demonstrated reductions in angiographic vasospasm, delayed cerebral ischemia incidence, rescue therapy utilization, or cerebral infarction burden. However, consistent improvement in long-term neurological recovery remained variable across studies. Emerging evidence increasingly supports a broader pathophysiological model of delayed cerebral ischemia involving endothelial dysfunction, microcirculatory impairment, neuroinflammation, and autonomic dysregulation in addition to proximal arterial narrowing. Contemporary neurovascular interventions may therefore represent an important shift toward more targeted and mechanistically informed therapeutic strategies after aneurysmal subarachnoid hemorrhage, although further large-scale multicenter investigations remain necessary to establish definitive clinical benefit.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.