Evidence map›Paper›PMID 42540841›Full record

ArticleInfection and drug resistance2026

Neuraminidase-Associated Vaginal Dysbiosis Correlates with HPV Infection Across Oncogenic Risk Subtypes.

Jiali Wang, Li Bai, Ning Leng, Yong Yang, Xia Cao, Wenhong Peng, Jingxuan Xu, Erfu Xie

Abstract read
In one paragraph

Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiali WangDepartment of Laboratory Medicine, Danyang Maternal and Child Health Hospital, Danyang, Jiangsu Province, 212300, People's Republic of China.
Li BaiDepartment of Laboratory Medicine, Danyang Maternal and Child Health Hospital, Danyang, Jiangsu Province, 212300, People's Republic of China.
Ning LengDepartment of Laboratory Medicine, Danyang Maternal and Child Health Hospital, Danyang, Jiangsu Province, 212300, People's Republic of China.
Yong YangDepartment of Laboratory Medicine, Danyang Maternal and Child Health Hospital, Danyang, Jiangsu Province, 212300, People's Republic of China.
Xia CaoDepartment of Gynecology, Danyang Maternal and Child Health Hospital, Danyang, Jiangsu Province, 212300, People's Republic of China.
Wenhong PengDepartment of Laboratory Medicine, Danyang Maternal and Child Health Hospital, Danyang, Jiangsu Province, 212300, People's Republic of China.
Jingxuan XuDepartment of Laboratory Medicine, Danyang Maternal and Child Health Hospital, Danyang, Jiangsu Province, 212300, People's Republic of China.
Erfu XieDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People's Republic of China.ORCID 0000-0002-6787-7646

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Human papillomavirus (HPV) infection is a major cause of cervical cancer, and increasing evidence suggests that cervicovaginal microbial dysbiosis may influence HPV susceptibility. This study evaluated the association between microbial enzymatic markers and HPV infection across different risk subtypes. Methods: A cross-sectional analysis was conducted in 43,426 women undergoing HPV screening. HPV status and subtype classification (high-, possible-, and low-risk) were determined using standardized genotyping. Clinical and laboratory parameters including age, white blood cells (WBC), red blood cells (RBC), vaginal pH, leukocyte esterase, fungal infection, Results: HPV positivity was identified in 20.6% of participants. Neuraminidase emerged as the most consistent independent predictor across all HPV categories (adjusted OR range: 1.437-1.828; Discussion: Neuraminidase-associated vaginal dysbiosis is strongly associated with HPV infection across multiple risk subtypes. These findings highlight the potential role of microbial functional biomarkers in understanding cervicovaginal dysbiosis and HPV susceptibility, particularly in populations vulnerable to microbial imbalance and secondary infections.

Indexed as

human papillomavirusimmunocompromised hostsmicrobial dysbiosisneuraminidasevaginal microbiome

Identifiers

PMID42540841
PMCPMC13426498

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.