ArticleThe journal of pain2026
Peri-adolescent ethanol exposure differentially affects mechanical and thermal sensitivity in rats.
Article in The journal of pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Chronic pain is exacerbated in individuals with alcohol use disorder (AUD) and often difficult to manage. Binge levels of ethanol intake during adolescence promotes AUD and comorbid chronic pain in adulthood. We and others have consistently reported adolescent ethanol exposure-associated augmentation in mechanical sensitivity during protracted abstinence in murine models. However, to date the effect of adolescent ethanol exposure on thermal hyperalgesia are mixed and dependent on sex and abstinence time. In this project we exposed Long Evans rats to air or ethanol intermittently throughout the peri-adolescent period (PD 28-68) and assessed mechanical sensitivity and thermal nociception weekly from Week 1 - 4 of abstinence. We observed baseline sex differences in mechanical allodynia and thermal hyperalgesia whereby air-exposed female rats exhibited greater sensitivity than the age-matched male rats. Furthermore, while ethanol exposure augmented mechanical sensitivity in both sexes, response to thermal nociception was specific to male rats. Our assessment of fear conditioning during protracted abstinence (Week 6) using a three-day context-dependent procedure revealed basal sex-differences whereby air-exposed female rats demonstrated lower retention of fear memory than male rats, but no aCIE exposure-associated changes in unconditioned or conditioned freezing in either sex. Together these results suggest that adolescent ethanol exposure-associated pain sensitivity varied depending on sex and pain modality. Importantly, enhanced pain sensitivity did not generalize to unconditioned or conditioned fear responses, and were not driven by differences in aversion-based learning. PERSPECTIVE: This article characterizes pain sensitivity in a rat model of adolescent alcohol exposure, overall suggesting that adolescent alcohol exposure potentiated pain sensitivity in adulthood. This model can be used in future studies to develop evidence-based pharmacotherapies to treat chronic pain in individuals with a history of high levels of alcohol misuse.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.