Evidence map›Paper›PMID 42542656›Full record

ArticleiScience2026

Evaluating exon skipping in the central nervous system in Duchenne muscular dystrophy using spatial transcriptomics.

Qirong Mao, Alireza Ahmadi, Sharon de Vries, Laura G M Heezen, Ophélie Vacca, Mathilde Doisy, Annemieke Aartsma-Rus, Maaike van Putten, Aurélie Goyenvalle, Ahmed Mahfouz and 1 more

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Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qirong MaoDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Alireza AhmadiDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Sharon de VriesDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Laura G M HeezenDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Ophélie VaccaUniversité Paris-Saclay, UVSQ, Inserm, END-ICAP, Versailles, France.
Mathilde DoisyUniversité Paris-Saclay, UVSQ, Inserm, END-ICAP, Versailles, France.
Annemieke Aartsma-RusDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Maaike van PuttenDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Aurélie GoyenvalleUniversité Paris-Saclay, UVSQ, Inserm, END-ICAP, Versailles, France.
Ahmed MahfouzDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Pietro SpitaliDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) causes progressive muscle degeneration due to dystrophin deficiency. Dystrophin is also expressed in the brain during development and postnatally, yet a characterization of dystrophin isoform expression across brain cells and regions is lacking, limiting our understanding of the cognitive impairment affecting one-third of the patients and hampering the development of dystrophin-restoring drugs in the central nervous system (CNS). Here, we applied spatial transcriptomics to map

Indexed as

central nervous systemDuchenne muscular dystrophydystrophin isoformsexon-skipping therapyspatial transcriptomics

Identifiers

PMID42542656
PMCPMC13427662

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.