ArticleAdvanced healthcare materials2026
Spatiotemporal Sonodynamic-Nanozymic Therapy for Infected Jawbone Defects.
Xin Liu, Zifan Zhao, Liujixiang Wang, Lei Tan, Fengxiao He, Gufeng Liu, Yang Xie, Bin Shi, Tao Wu, Haibin Xia
Abstract read
In one paragraphArticle in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
10 authors.
Xin LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.ORCID https://orcid.org/0009-0002-5210-7216 Zifan ZhaoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.
Liujixiang WangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.
Fengxiao HeState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.
Gufeng LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.
Yang XieState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.ORCID https://orcid.org/0009-0004-8821-1570 Bin ShiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.ORCID https://orcid.org/0000-0002-3643-9475 Tao WuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.
Haibin XiaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, P.R. China.ORCID https://orcid.org/0000-0003-2550-1146 Funding
National Natural Science Foundation of China 82201103Research Project of School and Hospital of Stomatology, Wuhan University ZW202403
6 · The paper itselfAbstract
Infectious jawbone defects, arising from open fractures, surgical contamination, or hematogenous pathogen spread, represent severe orthopedic complications characterized by concurrent bone loss and chronic infection. Precise control of pathogen colonization, effective modulation of local immune microenvironment, and activation of osteogenesis are spatiotemporal phases that pose significant clinical challenges. Here, we construct a multifunctional platform of copper-zinc bimetallic metal-organic nanosheets encapsulated in a polyvinylpyrrolidone-polyvinyl alcohol hydrogel (CuZn-MON@gel). Upon ultrasound irradiation, CuZn-MON produces singlet oxygen, achieving antibacterial efficiencies of 99.93% against Staphylococcus aureus and 99.78% against Porphyromonas gingivalis. In the absence of ultrasound, the nanozyme switches to SOD- and CAT-like activities, scavenging excess reactive oxygen species and downregulating pro-inflammatory pathways, including chemokine and NF-κB signaling pathway. Simultaneously, controlled release of osteogenic Cu
Indexed as
Anti-Bacterial AgentsJawUltrasonic TherapyAnimalsBone RegenerationCopperHumansMaleOsteogenesisPorphyromonas gingivalisRatsRats, Sprague-DawleyReactive Oxygen SpeciesStaphylococcus aureusZincAnti-Bacterial AgentsCopperReactive Oxygen SpeciesZincantibacterial therapyinfectious jaw defectsmetal–organic frameworkssonodynamic therapyspatiotemporal treatment
Identifiers
PMID42543504
PMCPMC13542869
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