ArticleBrain and behavior2026
Atherogenic Burden and Remnant Cholesterol Associate With Electrophysiological Severity in Carpal Tunnel Syndrome.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate whether composite lipid indices and remnant cholesterol (RC) are associated with electrophysiological severity in carpal tunnel syndrome (CTS) and to evaluate their independent discriminative performance for advanced disease stage.
methodsIn this cross-sectional case-control study, 124 patients with electrophysiologically confirmed CTS and 113 age- and sex-matched controls were included. CTS severity was graded according to the Padua classification. Fasting lipid profiles were obtained, and composite atherogenic indices including the triglyceride-to-high-density lipoprotein ratio (TG/HDL), the non-HDL/HDL ratio, and the atherogenic index of plasma (AIP) and RC were calculated. Between-group and severity-based comparisons were performed. Multivariable logistic regression was used to assess independent associations with advanced CTS (moderate-severe vs. mild), and receiver operating characteristic (ROC) analyses evaluated discriminative performance.
resultsCTS patients exhibited higher glucose, HbA1c, LDL-cholesterol, total cholesterol, and RC levels than controls (all p < 0.05), whereas composite indices did not significantly differ between groups. Within the CTS cohort, lipid parameters, composite indices, and RC varied significantly across electrophysiological stages. In multivariable analysis adjusted for age and sex, non-HDL/HDL ratio (OR = 2.99, 95% CI: 1.44-6.23), RC (OR = 3.12, 95% CI: 1.03-9.45), and AIP (OR = 0.27, 95% CI: 0.10-0.77) remained independently associated with advanced stage. The final model demonstrated moderate discriminative performance (area under the receiver operating characteristic curve [AUC] = 0.715, 95% CI: 0.619-0.811).
conclusionComposite lipid indices and RC are independently associated with electrophysiological severity rather than CTS presence. These findings support a severity-oriented metabolic framework in which systemic atherogenic burden may amplify median nerve dysfunction.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.