Evidence map›Paper›PMID 42543922›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

SIRT1 Exon 2-Encoded IDR Gates CREB-Dependent Transcriptional Timing During Fasting.

Arushi Shukla, Subinoy Adhikari, Chinthapalli Balaji, Sourankur Chakrabarti, Arshdeep Kaur, Jagannath Mondal, Ullas Kolthur-Seetharam

Abstract read
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In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arushi ShuklaDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.ORCID https://orcid.org/0009-0000-0698-3931
Subinoy AdhikariTata Institute of Fundamental Research-Hyderabad (TIFR-H), Hyderabad, India.
Chinthapalli BalajiDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
Sourankur ChakrabartiTata Institute of Fundamental Research-Hyderabad (TIFR-H), Hyderabad, India.
Arshdeep KaurDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
Jagannath MondalTata Institute of Fundamental Research-Hyderabad (TIFR-H), Hyderabad, India.
Ullas Kolthur-SeetharamDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.ORCID https://orcid.org/0000-0003-2612-1743

Funding

Department of Atomic Energy, Government of India (DAE) RT14003Department of Biotechnology, Ministry of Science and Technology, India (DBT) BT/PR29878/PFN/20/1431/2018Department of Science and Technology, Ministry of Science and Technology, India (DST) JCB/2022/000036Tata Institute of Fundamental Research (TIFR) 19P0116Tata Institute of Fundamental Research (TIFR) 19P0911
6 · The paper itself

Abstract

Metabolic adaptation to fasting requires precise temporal control of gene expression. Although transcription factors and upstream co-regulators that mediate the fasting response are well studied, the role of intrinsically disordered regions in coordinating transcriptional timing remains unclear. Here, we identify the exon 2-encoded intrinsically disordered region of SIRT1 as a regulator of fasting-responsive transcription in the liver. Using a physiological SIRT1

Indexed as

Cyclic AMP Response Element-Binding ProteinExonsFastingSirtuin 1Transcription, GeneticAnimalsGene Expression RegulationGluconeogenesisGlucoseLiverMaleMiceMice, Inbred C57BLCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinGlucoseSirt1 protein, mouseSirtuin 1fastingglucosehomeostasisinteractionslivermetabolism

Identifiers

PMID42543922
PMCPMC13430297

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.