ArticleCureus2026
Comparative Evaluation of Salivary Chemerin and Malondialdehyde Among Patients With Periodontitis and Oral Squamous Cell Carcinoma: A Cross-Sectional Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Periodontitis and oral squamous cell carcinoma (OSCC) are long-lasting inflammatory conditions that lead to tissue damage, oxidative stress, and changes in immune responses. Recent studies indicate a potential biological link between periodontal inflammation and the development of oral cancer. Salivary biomarkers such as chemerin and malondialdehyde (MDA) may serve as non-invasive tools for early diagnosis and disease monitoring. This study was designed to assess and compare salivary chemerin and MDA levels in three groups: healthy individuals, patients with periodontitis, and those with OSCC. Methods This study was conducted on 75 participants distributed evenly among the three groups: healthy individuals (Group A), periodontitis patients (Group B), and OSCC patients (Group C). Clinical periodontal parameters, including Oral Hygiene Index-Simplified (OHI-S), Russell's periodontal index, probing pocket depth (PPD), and clinical attachment level (CAL), were recorded. Unstimulated saliva samples were collected and analyzed for chemerin and MDA levels using enzyme-linked immunosorbent assay (ELISA) kits. Statistical analysis was done using analysis of variance (ANOVA), Tukey's post hoc test, and Pearson's correlation coefficient, with p<0.05 considered statistically significant. Results Salivary chemerin and MDA levels showed a progressive increase from healthy controls to periodontitis patients and OSCC patients. One-way ANOVA revealed statistically significant differences among the three groups for both chemerin (F(2,72)=4.28; p=0.017) and MDA (F(2,72)=3.45; p=0.037). Tukey's post hoc analysis demonstrated significant pairwise differences between all groups for both biomarkers (p<0.001), indicating increasing levels with disease severity. Pearson's correlation analysis showed a statistically significant positive correlation between chemerin and MDA, suggesting an association between inflammatory and oxidative stress pathways in periodontal disease. Conclusion Salivary chemerin and MDA levels were significantly increased in periodontitis and OSCC patients, with the highest levels observed in OSCC. These findings suggest that chemerin and MDA may serve as promising non-invasive salivary biomarkers for the diagnosis, risk assessment, and monitoring of periodontal disease and OSCC. Further large-scale longitudinal studies are recommended to validate their clinical applicability.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.