ReviewNigerian medical journal : journal of the Nigeria Medical Association
Pattern of Expression of Oestrogen and Progesterone Receptors in Ovarian Carcinoma from a Tertiary Center in Nigeria: A 10-Year Retrospective Study.
Review in Nigerian medical journal : journal of the Nigeria Medical Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ovarian cancer (OC) is the seventh most common malignancy among women globally and a major cause of cancer-related mortality, with approximately 239,000 new cases and 152,000 deaths each year. Despite extensive research, there is currently no effective public health screening method for early detection, as commonly used investigations such as CA-125 testing, transvaginal ultrasonography, and bimanual examination lack sufficient diagnostic accuracy. This study evaluated the patterns of oestrogen receptor (ER) and progesterone receptor (PR) expression in ovarian cancer cases in Kano State, Nigeria. Methodology: Relevant demographic data were obtained from laboratory records. Archival formalin-fixed, paraffin-embedded tissue blocks were examined using haematoxylin and eosin staining, followed by immunohistochemical analysis for ER and PR. Tumours were classified according to histological type and grade, and receptor expression was assessed based on immunostaining. Statistical analysis was performed using SPSS, version 26. Result: Sixty ovarian cancer cases were analysed, with patient ages ranging from 10 to 75 years (mean age 52 ± 14 years). High-grade serous carcinoma (HGSC) was the predominant histological subtype, accounting for 63.3% of cases, followed by mucinous carcinoma (15%). Endometrioid carcinoma and malignant Brenner tumour each represented 8.3% of cases, while low-grade serous carcinoma was the least common (5%). Most cases occurred in the sixth decade of life, with HGSC comprising 74% of tumours in this age group. Oestrogen receptor (ER) positivity was observed in 40% of cases, with HGSC showing the highest ER expression. In contrast, progesterone receptor (PR) positivity was low (15%), with most PR-positive cases also being HGSC. Conclusion: OC incidence increased with age, predominantly affecting women aged 50 years and above. The relatively high ER expression and low PR expression highlight the potential role of hormone receptor profiling in guiding personalised treatment strategies for ovarian cancer in this setting.
Indexed as
Identifiers
42544305PMC13429063What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.