ArticleAnnals of medicine2026
Association between perioperative D-dimer dynamics and post-treatment localized intravascular coagulation in venous malformations.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
objectiveTo investigate the association between the change in D-dimer levels (ΔD-dimer) and the development of localized intravascular coagulation (LIC) following surgical intervention in patients with venous malformations.
methodsThis retrospective cohort study enrolled 267 patients with venous malformations who underwent surgical treatment at Fujian Maternity and Child Health Hospital between June 2021 and December 2025. The primary exposure variable was the preoperative-to-postoperative ΔD-dimer. The principal outcome was postoperative LIC. Multivariable logistic regression analysis was employed to estimate the effect size, adjusted for potential confounders.
resultsThe incidence of LIC was 31.1% (83/267). Each unit increase in ΔD-dimer was significantly associated with a higher risk of LIC (adjusted odds ratio [aOR] = 2.51; 95% confidence interval [CI]: 1.93-3.26;
conclusionΔD-dimer is independently associated with postoperative LIC in patients with venous malformations, demonstrating a significant dose-response relationship. Collectively, these findings suggest that ΔD-dimer is independently associated with postoperative LIC and may serve as a risk marker for perioperative coagulation monitoring.
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