Evidence map›Paper›PMID 42545015›Full record

ReviewJournal of virology2026

The polymerase milieu of human papillomavirus.

Keira R Ylvisaker, Gopishankar Thirumoorthy, Emma Wisniewski, Kavi P M Mehta

Abstract readReview
In one paragraph

Review in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Keira R YlvisakerDepartment of Comparative Biosciences, University of Wisconsin-Madison School of Veterinary Medicine, Madison, Wisconsin, USA.
Gopishankar ThirumoorthyDepartment of Comparative Biosciences, University of Wisconsin-Madison School of Veterinary Medicine, Madison, Wisconsin, USA.
Emma WisniewskiDepartment of Comparative Biosciences, University of Wisconsin-Madison School of Veterinary Medicine, Madison, Wisconsin, USA.
Kavi P M MehtaDepartment of Comparative Biosciences, University of Wisconsin-Madison School of Veterinary Medicine, Madison, Wisconsin, USA.ORCID 0000-0002-2582-073X

Funding

NCI NIH HHS L70 CA294320
6 · The paper itself

Abstract

High-risk human papillomaviruses (HPVs) cause cervical, anogenital, and head and neck cancers. A key oncogenic mechanism involves viral exploitation of host DNA damage tolerance pathways to support productive replication, a process that also drives genomic instability. Despite evidence that specific cellular polymerases participate in HPV genome replication, the full complement of polymerases deployed across the viral life cycle remains poorly defined. This minireview examines the potential roles of both replicative and translesion synthesis (TLS) polymerases at distinct stages of the HPV life cycle, and new tools that can be used to assess their potential importance in driving cancer, the life cycle, and altering mutagenic potential.

Indexed as

DNA-Directed DNA PolymeraseHuman Papillomavirus VirusesPapillomaviridaePapillomavirus InfectionsVirus ReplicationDNA DamageDNA RepairDNA ReplicationDNA, ViralGenome, ViralGenomic InstabilityHumansTranslesion DNA SynthesisDNA-Directed DNA PolymeraseDNA, ViralDNA damageDNA repairHPVmutagenesisreplicationreplisometumor viruses

Identifiers

PMID42545015
PMCPMC13595947

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.