Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis.

Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha

Abstract read

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yang HongSchool of Medicine and Health, Zhengzhou Advanced Research Institute of Harbin Institute of Technology, Zhengzhou, China.ORCID https://orcid.org/0009-0005-7235-7994

Haitao WuSchool of Biomedical Engineering, Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0007-8769-9190

Weitao WangSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, China.ORCID https://orcid.org/0009-0000-9257-0817

Xuan ZhangSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, China.

Qian ChenSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, China.

Yaoyu HuSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, China.ORCID https://orcid.org/0009-0003-1173-021X

Zhengbao ZhaSchool of Medicine and Health, Zhengzhou Advanced Research Institute of Harbin Institute of Technology, Zhengzhou, China.ORCID https://orcid.org/0000-0003-3646-4969

Funding

Henan Province Zhongyuan Leading Talent Project 254200510053National Natural Science Foundation of China 52272275National Natural Science Foundation of China 52522215

6 · The paper itself

Abstract

Cellular pyroptosis, a pro-inflammatory form of programmed cell death, emerges as a promising strategy for cancer immunotherapy. However, gene methylation hampers the expression of gasdermin E (GSDME), a pivotal protein in the caspase-3-mediated pyroptosis pathway, across numerous malignancies, including triple-negative breast cancer (TNBC). This study elucidated that a colloidal hydrogel (GDLC hydrogel) loaded with decitabine (DAC) and crosslinked with lanthanum carbonate nanosheets (LCNSs) and gelatin nanoparticles (Gela NPs) could instigate pyroptosis in TNBC cells, specifically 4T1 cells. Within the tumor microenvironment (TME), the synergistic interaction between DAC and La

Indexed as

colloidal hydrogelGSDMEimmunotherapylanthanum carbonate nanosheetspyroptosis

Identifiers

PMID42545190

DOI10.1002/advs.76966

PMCPMC13430939

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.