ArticleInternational journal of legal medicine2026
Cardiac blood phenethylamine as a potential biomarker for post-mortem interval in forensic autopsy cases.
Article in International journal of legal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In forensic autopsy, estimating post-mortem interval (PMI) requires a combined analysis of macroscopic findings with histopathological, biochemical, and toxicological data. However, accurate assessment of PMI remains challenging, particularly in cases with advanced decomposition. Phenethylamine (PEA), a putrefactive amine, has been identified in various post-mortem samples including blood, tissues, and body surfaces. This study aimed to evaluate the association between cardiac blood PEA concentrations collected during forensic autopsies and PMI in forensic autopsy cases. Cardiac blood samples from 361 forensic autopsy cases were collected over 6 years and analyzed using ultra-high-performance liquid chromatography-tandem mass spectrometry. PMI ranged from 0.5 to 150 days (median: 1.29), whereas PEA levels ranged from 0 to 115.2 µg/mL (median: 0 µg/mL). When all cases were included, a moderate association was observed between PEA concentration and PMI (R
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