Evidence map›Paper›PMID 42547468›Full record

ArticleAllergy, asthma & immunology research2026

Eucalyptol-Limonene-Pinene Attenuates Mucus Hypersecretion and Inflammation via Multitarget Mechanisms in Chronic Rhinosinusitis With Nasal Polyps.

Yuan Zhang, Jian Jiao, Mengyan Zhuang, Qinqin Zhang, Ting He, Ying Li, Yutong Sima, Xiangdong Wang, Luo Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, asthma & immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuan Zhang *Department of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0001-7164-2604
Jian Jiao *Department of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-0716-2654
Mengyan ZhuangDepartment of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0001-0594-3564
Qinqin ZhangDepartment of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-1200-7245
Ting HeDepartment of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0009-4005-1092
Ying LiDepartment of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-3343-4492
Yutong SimaDepartment of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-4537-8125
Xiangdong WangDepartment of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-0409-322X
Luo ZhangDepartment of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-0910-9884

Funding

Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes, Beijing Municipal Health Commission JYY2021-2Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes, Beijing Municipal Health Commission JYY2023-1Beijing Nova Program 20240484625China International Medical Foundation Z-2018-31-2108National Key Research and Development Program of China 2022YFC2504100National Natural Science Foundation of China 82171110National Natural Science Foundation of China 82471137Natural Science Foundation of Beijing Municipality 7252009Program for Changjiang Scholars and Innovative Research Team in University IRT13082Special Funds for the Construction of High-level Public Health Technical Talents Lingjunrencai-01-08Special Funds for the Construction of High-level Public Health Technical Talents Lingjunrencai-02-09
6 · The paper itself

Abstract

purposeChronic rhinosinusitis with nasal polyps (CRSwNP) is a common chronic inflammatory disease of the mucosa, which significantly impairs patients' quality of life. Eucalyptol-Limonene-Pinene (ELP) is a plant-derived mucoactive agent used in respiratory diseases, including CRSwNP; however, its underlying mechanisms remain unclear. This study aimed to evaluate ELP's effect on CRSwNP and explore its mechanisms.

methodsPredicted targets and pathways from network pharmacology were validated

resultsNetwork pharmacology revealed that epidermal growth factor receptor (EGFR), hypoxia-inducible factor 1-alpha, interleukin (IL)-2 are core targets and enriched in inflammation pathways.

conclusionsELP reduced mucus hypersecretion and inflammatory mediators

Indexed as

alpha-pineneepidermal growth factor receptorEucalyptolhypoxiainterleukin-13interleukin-2limonenemucin 5ACmucusnasal polypspharmacology

Identifiers

PMID42547468
PMCPMC13441558

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.