Evidence map›Paper›PMID 42547570›Full record

ArticleEuropean journal of clinical pharmacology2026

Cognitive function in the context of pharmacogenetic CYP2D6 variability and anticholinergic burden in older adults - results from the ActiFE study.

Linda Lorenz, Judith Berres, Michael D Denkinger, Dietrich Rothenbacher, Stefanie Braig, Dhayana Dallmeier, Katja S Just

Abstract read
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In one paragraph

Article in European journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linda LorenzInstitute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0009-0001-3050-5232
Judith BerresInstitute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0009-0000-5463-7777
Michael D DenkingerInstitute for Geriatric Research, Ulm University Medical Centre, Ulm, Germany.ORCID http://orcid.org/0000-0002-8097-060X
Dietrich RothenbacherInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.ORCID http://orcid.org/0000-0002-3563-2791
Stefanie BraigInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Dhayana DallmeierInstitute for Geriatric Research, Ulm University Medical Centre, Ulm, Germany.ORCID http://orcid.org/0000-0003-3665-7023
Katja S JustInstitute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, Germany. kjust@ukaachen.de.ORCID http://orcid.org/0000-0002-6782-8078

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the role of CYP2D6 and its pharmacogenetic variability in the association between anticholinergic burden and cognitive function in older adults.

methodsWe conducted a cross-sectional analysis of 872 community-dwelling adults ≥ 65 years from the ActiFE-Ulm cohort. Cognitive performance was assessed using the Mini-Mental State Examination (MMSE). Anticholinergic burden scores deriving from CYP2D6-metabolised drugs (ABS

resultsABS

conclusionThese exploratory findings suggest that CYP2D6 metaboliser status may contribute to interindividual susceptibility to anticholinergic burden-related lower cognitive performance. If confirmed in larger longitudinal studies, pharmacogenetic information may support more individualised anticholinergic risk assessment and safer prescribing in older adults.

Indexed as

Cholinergic AntagonistsCognitionCytochrome P-450 CYP2D6AgedAged, 80 and overCross-Sectional StudiesFemaleGenotypeHumansMalePharmacogeneticsPharmacogenomic VariantsCholinergic AntagonistsCytochrome P-450 CYP2D6Anticholinergic burdenCognitive impairmentCYP2D6Older adultsPharmacogenetics

Identifiers

PMID42547570
PMCPMC13433654

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.