ArticleJournal of cardiovascular translational research2026
Autoantibody-Based Models for the Diagnosis and Activity Assessment of Takayasu Arteritis.
Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The precise diagnosis and activity assessment of Takayasu arteritis (TA) remain challenging. Using a two-phase approach, we screened serum from 9 TA patients and 10 healthy controls via HuProt microarrays, identifying three novel autoantibodies (anti-Table 2, anti-TRAC, anti-LILRA5). These were validated by ELISA in 175 samples (61 active TA, 42 inactive TA, 72 controls). Logistic regression models were developed from training (70%) and test (30%) sets. For diagnosis, Model 1 achieved AUCs of 0.88 and 0.86, outperforming CRP (0.58) and ESR (0.61). For activity assessment, Model 2 achieved AUCs of 0.78 and 0.79, superior to CRP (0.62) and ESR (0.58). These novel autoantibody-based models enable accurate, non-invasive diagnosis and activity assessment in TA.
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