Evidence map›Paper›PMID 42547848›Full record

ArticleNature cardiovascular research2026

Pericyte K

Danielle A Jeffrey, Eric W Prince, Niloufar Khakpour, Hannah R Ferris, Colin H Peters, Gregory Seedorf, Phinea Z Romero, Mayra Bueno Guerrero, Abigail N Russell, Katherine Glodoski and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A balancing act keeps the brain fed.Nature cardiovascular research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Danielle A JeffreyDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-9576-9458
Eric W PrinceDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Niloufar KhakpourDepartment of Biomedical Engineering, Florida International University, Miami, FL, USA.
Hannah R FerrisDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Colin H PetersDepartment of Physiology & Biophysics and Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Gregory SeedorfDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Phinea Z RomeroDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Mayra Bueno GuerreroDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Abigail N RussellDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Katherine GlodoskiDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Gregory L FutiaDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Stephanie K BonneyDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Michael A ThorntonThe Salk Institute for Biological Studies, La Jolla, CA, USA.
Emily A GibsonDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-2266-9525
Catherine ProenzaDepartment of Physiology & Biophysics and Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Anastacia M GarciaDepartment of Pediatrics, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Nikolaos M TsoukiasDepartment of Biomedical Engineering, Florida International University, Miami, FL, USA.
Fabrice DabertrandDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Fabrice.Dabertrand@CUAnschutz.edu.ORCID http://orcid.org/0000-0003-2541-9185

Funding

PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1M
Capillary control of cerebral blood flow, and its disruption in small vessel diseaseR01HL136636 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Fabrice Dabertrand · 2017 to 2026
$3.8M
Cerebral Microvascular Signaling and Neurovascular Coupling: An Integrated Approach to Investigate VCIDR01NS119971 · NINDS · FLORIDA INTERNATIONAL UNIVERSITY · PI TSOUKIAS, NIKOLAOS MICHAEL · 2021 to 2025
$2.6M
Brain capillary endothelial cell energetics and neurovascular uncoupling in dementiaRF1NS140137 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DABERTRAND, FABRICE, GARCIA, ANASTACIA M · 2024 to 2024
$2.4M
Rescuing neurovascular coupling to protect neuronal plasticity and cognitionRF1NS129022 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DABERTRAND, FABRICE, DELL'ACQUA, MARK L · 2022 to 2022
$1.8M
Rescuing neurovascular coupling to protect neuronal plasticity and cognitionR01NS129022 · NINDS · UNIVERSITY OF COLORADO DENVER · PI MARK L DELL'ACQUA, Fabrice Dabertrand · 2025 to 2026
$1.1M
Pericyte KATP channel hyperactivity in cerebral small vessel diseaseF31HL170645 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI JEFFREY, DANIELLE A · 2023 to 2025
$120k
Kir2.1 channel dysfunction underlies neurovascular coupling impairment in autismF31HL184931 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Phinea Z Romero · 2026 to 2026
$39k
Fondation Leducq 22CVD01 BRENDANHLBI NIH HHS F31 HL170645NHLBI NIH HHS F31 HL184931NHLBI NIH HHS R01 HL136636NIGMS NIH HHS T32 GM007635NINDS NIH HHS R01 NS119971NINDS NIH HHS R01 NS129022NINDS NIH HHS RF1 NS129022NINDS NIH HHS RF1 NS140137U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL170645U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL136636U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 5T32GM007635U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) F31HL184931U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS119971U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RF1NS129022U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RF1NS140137
6 · The paper itself

Abstract

Cerebral hemodynamic dysfunction is a key driver of unhealthy brain aging. Impaired microcirculatory reactivity leads to uneven perfusion, rendering deeper brain regions more vulnerable and thereby contributing to cognitive decline. Yet how capillaries contribute to these deficits remains poorly defined. Here we combined spatial transcriptomics with in vivo two-photon and three-photon imaging to measure layer-specific cerebral blood flow in control and small vessel disease model mice (CADASIL TgNotch3R169C). We found downregulation of ATP-synthesizing genes, indicating microvascular metabolic impairment that paralleled impaired pericyte bioenergetics. This energy deficit coincided with diminished tone in the arteriole-capillary transitional zone and reduced deep-layer perfusion. Complementary electrophysiology, ex vivo and in silico approaches, revealed that hyperactive K

Indexed as

CADASILCerebral CortexCerebrovascular CirculationKATP ChannelsMicrocirculationPericytesAdenosine TriphosphateAnimalsBlood Flow VelocityDisease Models, AnimalEnergy MetabolismMaleMiceMice, Inbred C57BLMice, TransgenicSpatial TranscriptomicsAdenosine TriphosphateKATP Channels

Identifiers

PMID42547848
PMCPMC13461346

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.