Evidence mapPaperPMID 42547951Full record

Trial reportPediatric obesity2026

Pilot Randomised Trial of Calibrated Formula Volumes to Optimise Growth in Infants at Risk for Overweight: The Califormula Randomised Clinical Trial.

Ian M Paul, Bernardo L Horta, Mina Desai, Michael G Ross

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Pediatric obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05104073 (Califormula Study), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05104073 nacompletednot on this map

Califormula Study: Calibrated Formula Feeding to Optimize Infant Growth

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2022 to 2024Enrolled60ConditionsOverweight and ObesityArmsIntervention
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ian M PaulPenn State College of Medicine, Hershey, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-6344-8609
Bernardo L HortaSchool of Medicine, Universidade Federal de Pelotas, Pelotas, Brazil.ORCID https://orcid.org/0000-0001-9843-412X
Mina DesaiThe Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.ORCID https://orcid.org/0000-0002-0192-0189
Michael G RossThe Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2025 to 2025
$3.8M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R21HD104028NCATS NIH HHS UL1TR002014
6 · The paper itself

Abstract

backgroundFormula feeding and having a mother with overweight are associated with overweight during infancy.

objectivesWe sought to pilot test calibrated formula feeding guidance using age and weight specific intake recommendations to improve weight outcomes amongst at-risk infants.

methodsExclusively formula fed newborns with birthweight ≥ 50th percentile delivered to mothers with pre-pregnancy body mass index (BMI) ≥ 25 kg/m

resultsSixty infants were enrolled; 36 mothers (66.7%) had pre-pregnancy BMI ≥ 30. Seventeen (28.3%) withdrew before 6 months. At each assessment, a minority had WFL ≥ 75th percentile required to receive calibrated formula guidance. There were no group differences in CWG (intervention mean 0.27, 95% CI -0.20 to 0.75 vs. control mean -0.12, 95% CI -0.62 to 0.37; p = 0.25) or for secondary outcomes.

conclusionsCalibrated infant formula recommendations were not associated with growth outcomes.

trial registrationClinicaltrials.gov identifier: NCT05104073 (registered October 11, 2021).

Indexed as

Infant FormulaOverweightPediatric ObesityWeight GainAdultBirth WeightBody Mass IndexChild DevelopmentFemaleHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaMalePilot ProjectsPregnancygrowthinfant formulaoverweight

Identifiers

PMID42547951
PMCPMC13433827

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.