Evidence map›Paper›PMID 42548015›Full record

ArticleAdvanced healthcare materials2026

Peptide Coacervates as Dynamic and Interactive Depots for Tetrodotoxin in Long-Acting Local Anesthesia.

Xing Wang, Jiahao Zhang, Wen Liu, Wanqi Wang, Zeyu Zhang, Christina Tran, Qing Huang, Tianyu Yao, Zufeng Ding, Wei Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xing WangDepartment of Chemistry, Georgia State University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-6080-4540
Jiahao ZhangDepartment of Chemistry, Georgia State University, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0000-5536-925X
Wen LiuDepartment of Chemistry, Georgia State University, Atlanta, Georgia, USA.
Wanqi WangDepartment of Chemistry, Georgia State University, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0008-2656-4644
Zeyu ZhangDepartment of Chemistry, Georgia State University, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0003-9405-6098
Christina TranDepartment of Chemistry, Georgia State University, Atlanta, Georgia, USA.
Qing HuangDepartment of Chemistry, Georgia State University, Atlanta, Georgia, USA.
Tianyu YaoDepartment of Chemistry, Georgia State University, Atlanta, Georgia, USA.
Zufeng DingDepartment of Biology, Georgia State University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-8643-7059
Wei ZhangDepartment of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-9321-6411
Zhicheng JinDepartment of Chemistry, Georgia State University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-6072-7533

Funding

A Xevo G2-XS Mass Spectrometer Equipped with an Acquity UPLC as a Workhorse Instrument to Replace a 15-year old Waters Q-TOF MicroS10OD026764 · OD · GEORGIA STATE UNIVERSITY · PI WANG, SIMING · 2020 to 2020
$428k
ACS Petroleum Research Fund 69450-DNI4Molecular Basis of Disease FellowshipNIH HHS 1S10OD026764-01NIH HHS S10 OD026764
6 · The paper itself

Abstract

Hydrophilic small-molecule therapeutics are difficult to encapsulate using conventional depot delivery systems because of their high-water solubility and rapid diffusion. Here we report a drug-interactive peptide coacervate platform for sustained release of tetrodotoxin (TTX), a potent site-1 sodium channel blocker used for local anesthesia. We discovered that a mussel foot protein-inspired peptide (Mfp3s-pep) interacts with TTX and undergoes spontaneous self-coacervation under physiological conditions, forming dynamic assemblies that encapsulate TTX via multivalent noncovalent interactions. The Mfp3s-pep coacervates sequester 29% of TTX and significantly prolong its release. In a rat sciatic nerve block model, the TTX-Mfp3s-pep formulation extended sensory blockade up to 10.5 h and reduced systemic toxicity by 1.5-fold, which had not been achievable with TTX alone without drug synergy. Molecular docking and molecular dynamics simulations further reveal that coacervate structures stabilize TTX through a dynamic hydrogen-bonding network and multivalent interactions. This work establishes peptide coacervates as a potential platform for delivery of hydrophilic therapeutics.

Indexed as

Anesthesia, LocalAnesthetics, LocalPeptidesTetrodotoxinAnimalsDelayed-Action PreparationsMolecular Docking SimulationMolecular Dynamics SimulationRatsRats, Sprague-DawleySciatic NerveAnesthetics, LocalDelayed-Action PreparationsPeptidesTetrodotoxincoacervateslocal anesthesiapeptidesustained releasetetrodotoxin

Identifiers

PMID42548015
PMCPMC13542959

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.